{"id":"W2617478173","doi":"10.1039/c7mt00133a","title":"La(<scp>iii</scp>) biodistribution profiles from intravenous and oral dosing of two lanthanum complexes, La(dpp)<sub>3</sub> and La(XT), and evaluation as treatments for bone resorption disorders","year":2017,"lang":"en","type":"article","venue":"Metallomics","topic":"Lanthanide and Transition Metal Complexes","field":"Materials Science","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatoon Medical Imaging; University of Saskatchewan; Vancouver Biotech (Canada); University of British Columbia","funders":"American Society for Bone and Mineral Research; Canadian Institutes of Health Research; University of Arizona Cancer Center","keywords":"Biodistribution; Lanthanum; In vivo; Chemistry; Bone resorption; Resorption; Chelation; Oral administration; Pharmacokinetics; Pharmacology; Radiochemistry; Nuclear chemistry; In vitro; Biochemistry; Internal medicine; Medicine; Inorganic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001481686,0.0001737799,0.0001686439,0.0001640704,0.00008454635,0.0002853884,0.0001463879,0.0002731682,0.001845393],"category_scores_gemma":[0.0002148248,0.0001510817,0.00016496,0.0001970861,0.0002609524,0.0001883709,0.00007803256,0.0005372646,0.0003049207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002304718,"about_ca_system_score_gemma":0.0003538493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001849716,"about_ca_topic_score_gemma":0.001645228,"domain_scores_codex":[0.9999431,0.00001109676,0.000002418398,0.00001219997,0.00001350331,0.00001774125],"domain_scores_gemma":[0.9998999,0.00003163211,0.00002400782,0.00001046577,0.00001694657,0.00001712603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007375448,0.000124763,0.0009335935,0.00006622869,0.00002512629,0.000104468,0.00004698087,0.000613322,0.9759679,0.000195532,0.0005030151,0.0140436],"study_design_scores_gemma":[0.00009024346,0.002806064,0.02172043,0.0000102869,0.0001112796,0.0006503961,0.00008730462,0.00233043,0.9693261,0.0001445401,0.002703698,0.00001930055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900936,0.001380109,0.00366266,0.00009353032,0.00002090449,0.00004255233,0.00155053,0.0001516807,0.003004471],"genre_scores_gemma":[0.9912542,0.0009957432,0.001734411,0.00009800026,0.000007972097,0.00005095506,0.001384577,0.0001060133,0.004368261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001849716,"threshold_uncertainty_score":0.006173432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02916879067084999,"score_gpt":0.2936721869884215,"score_spread":0.2645033963175715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}