{"id":"W2617478173","doi":"10.1039/c7mt00133a","title":"La(<scp>iii</scp>) biodistribution profiles from intravenous and oral dosing of two lanthanum complexes, La(dpp)<sub>3</sub> and La(XT), and evaluation as treatments for bone resorption disorders","year":2017,"lang":"en","type":"article","venue":"Metallomics","topic":"Lanthanide and Transition Metal Complexes","field":"Materials Science","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatoon Medical Imaging; University of Saskatchewan; Vancouver Biotech (Canada); University of British Columbia","funders":"American Society for Bone and Mineral Research; Canadian Institutes of Health Research; University of Arizona Cancer Center","keywords":"Biodistribution; Lanthanum; In vivo; Chemistry; Bone resorption; Resorption; Chelation; Oral administration; Pharmacokinetics; Pharmacology; Radiochemistry; Nuclear chemistry; In vitro; Biochemistry; Internal medicine; Medicine; Inorganic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009949865,0.0001884387,0.0003477796,0.00006560689,0.0003635279,0.000305038,0.00009185111,0.000101166,0.000003720311],"category_scores_gemma":[0.0001824989,0.000165934,0.00004792989,0.00003665316,0.00040941,0.000378346,0.00006829539,0.0000664011,0.000002482271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002825082,"about_ca_system_score_gemma":0.00003722784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008404506,"about_ca_topic_score_gemma":0.0006131784,"domain_scores_codex":[0.9986771,0.0002891452,0.0002718443,0.0003528311,0.0002170299,0.0001920392],"domain_scores_gemma":[0.9990107,0.0003474578,0.0002813176,0.000207859,0.0000818356,0.00007078095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001103962,0.00009502635,0.001429456,0.00005294436,0.0000628519,0.000001753184,0.0004739872,0.000004520845,0.9868055,0.001949997,0.00001101603,0.009002579],"study_design_scores_gemma":[0.003967761,0.0002429501,0.06965366,0.00007506219,0.000593729,0.00003291426,0.0002722866,0.001482533,0.893097,0.03022698,0.0002129629,0.0001421673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951631,0.0004562508,0.002658232,0.00005794968,0.0001062438,0.0005968939,0.0008170036,0.00002843317,0.0001158351],"genre_scores_gemma":[0.9961432,0.000547453,0.002721869,0.00001134506,0.00003905963,0.00004471292,0.0004715422,0.00001557954,0.00000526737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09370847,"threshold_uncertainty_score":0.676659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02916879067084999,"score_gpt":0.2936721869884215,"score_spread":0.2645033963175715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}