{"id":"W2617485063","doi":"10.21037/jphe.2017.02.04","title":"Additive effects of gene regulatory variants in multifactorial disease","year":2017,"lang":"en","type":"article","venue":"Journal of Public Health and Emergency","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Gene; Genetics; Computational biology; Disease; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003953338,0.00008347609,0.0001846817,0.00006829679,0.0001059311,0.00001362911,0.0001686243,0.00005458752,0.00001656918],"category_scores_gemma":[0.0008977258,0.00007054561,0.00008431384,0.00002333175,0.00004306524,0.00001452699,0.00004844802,0.00006731864,3.419446e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001424932,"about_ca_system_score_gemma":0.0006588494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004197272,"about_ca_topic_score_gemma":0.00001724759,"domain_scores_codex":[0.9990858,0.00008579987,0.0003863096,0.0001193188,0.0001174261,0.0002052866],"domain_scores_gemma":[0.9985206,0.000008190947,0.0005209966,0.0002159351,0.0001439553,0.0005903277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001728432,0.002452711,0.5274268,0.001509141,0.0005313332,0.0003501361,0.00183753,0.00001650388,0.1665723,0.0008053649,0.02571019,0.2710595],"study_design_scores_gemma":[0.001363484,0.0004279327,0.9894937,0.00004777206,0.00001055074,0.000009209112,0.00006778659,0.00001345073,0.001286827,0.0001529268,0.007025089,0.0001012295],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923431,0.005527087,0.0001558046,0.000465525,0.001323162,0.00009818697,0.00003945367,6.588226e-7,0.0000470074],"genre_scores_gemma":[0.9940053,0.005113144,0.0001323211,0.00006008711,0.0006228941,0.0000022244,0.00001667444,0.000007757822,0.00003959142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4620669,"threshold_uncertainty_score":0.2876767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01946204723050003,"score_gpt":0.2972029394970108,"score_spread":0.2777408922665108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}