{"id":"W2617492910","doi":"10.1093/neuonc/nox083.091","title":"HGG-02. DIANHYDROGALACTITOL (VAL-083) OVERCOMES MGMT- AND P53-MEDIATED CHEMO-RESISTANCE AND DISPLAYS SYNERGY WITH TOPOISOMERASE INHIBITORS","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Delmar (Canada); University of British Columbia","funders":"","keywords":"Temozolomide; Cancer research; Topoisomerase; DNA repair; Medicine; DNA damage; Methyltransferase; Cancer; Cell cycle; Oncology; Internal medicine; Glioma; Biology; In vitro; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004217423,0.0003967537,0.0002146762,0.0002123327,0.00007836903,0.0001659979,0.00025269,0.0001985529,0.001437125],"category_scores_gemma":[0.0000487731,0.00009273965,0.0002231635,0.0002162505,0.0001177441,0.00009132881,0.0001653534,0.0006044029,0.0004095454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002118062,"about_ca_system_score_gemma":0.0002213664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001208448,"about_ca_topic_score_gemma":0.001995219,"domain_scores_codex":[0.9999582,0.000007772851,0.000002314302,0.000006701984,0.000009504244,0.00001557743],"domain_scores_gemma":[0.9999701,0.000002306068,0.000007050473,0.000002981765,0.000002722898,0.00001490743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001329412,0.0006470265,0.0006350398,0.0001735677,0.00004101953,0.0001823022,0.00003702153,0.0008015465,0.9546556,0.0003317159,0.001370888,0.03979469],"study_design_scores_gemma":[0.0005978644,0.008048982,0.009190889,0.00001839844,0.00007614313,0.001271741,0.00003586061,0.001473539,0.9532382,0.0001195306,0.02590952,0.0000193118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865147,0.005345002,0.0008862253,0.0002681353,0.00005717496,0.00007778835,0.0009018475,0.0004158841,0.005533325],"genre_scores_gemma":[0.9932059,0.001914548,0.0009818063,0.0001118135,0.00001190099,0.00003397528,0.001422482,0.00002920136,0.002288324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001437125,"threshold_uncertainty_score":0.004807651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01031592329681333,"score_gpt":0.2694795276353134,"score_spread":0.2591636043385001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}