{"id":"W2617563780","doi":"10.1016/j.pharmthera.2017.05.005","title":"Cytochrome P450-derived eicosanoids and heart function","year":2017,"lang":"en","type":"review","venue":"Pharmacology & Therapeutics","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Cytochrome P450; Arachidonic acid; Epoxygenase; Polyunsaturated fatty acid; CYP2C8; Monooxygenase; Biochemistry; Biology; Thromboxanes; Isozyme; Docosahexaenoic acid; Hydroxyeicosatetraenoic acid; Metabolism; Linoleic acid; Fatty acid; Enzyme; CYP2C9","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003306658,0.0007298476,0.001561653,0.0001670399,0.0004748041,0.00007306164,0.0005497172,0.001076107,0.0002158982],"category_scores_gemma":[0.000007601479,0.0006353959,0.0004654796,0.00007890802,0.0005277775,0.00001005614,0.0004570476,0.0006915891,0.00009753879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003515827,"about_ca_system_score_gemma":0.0003754764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003827844,"about_ca_topic_score_gemma":0.000003785517,"domain_scores_codex":[0.997197,0.0004823682,0.0005779463,0.0009659987,0.000148397,0.0006282876],"domain_scores_gemma":[0.998476,0.00007195867,0.0004588935,0.0006346254,0.0001363917,0.0002221613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001632739,0.0002373068,0.00001246327,0.001615757,0.003096555,0.00003780907,0.00001863322,6.466083e-7,0.4416838,0.00002250327,0.01741298,0.5356983],"study_design_scores_gemma":[0.0009739035,0.0005717147,0.00007686345,0.0001736743,0.005587281,0.000323819,0.000004971372,0.000007837045,0.001845023,0.00002733694,0.9897847,0.0006229454],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001303334,0.9954662,0.00005936671,0.0003448049,0.001448234,0.0009327194,0.00008897455,0.00005172862,0.0003046732],"genre_scores_gemma":[0.001141724,0.987291,0.000114245,0.008511116,0.001442427,0.0002463309,0.0003487003,0.0001427306,0.000761668],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9723716,"threshold_uncertainty_score":0.9996097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.129113933596096,"score_gpt":0.4184665365005942,"score_spread":0.2893526029044982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}