{"id":"W2617736527","doi":"10.7150/thno.18136","title":"Surface De-PEGylation Controls Nanoparticle-Mediated siRNA Delivery <i>In Vitro</i> and <i>In Vivo</i>","year":2017,"lang":"en","type":"article","venue":"Theranostics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Institutes of Health; Movember Foundation; National Cancer Institute; Prostate Cancer Foundation","keywords":"PEGylation; Chemistry; In vivo; Small interfering RNA; Gene silencing; Ethylene glycol; Biophysics; PEG ratio; In vitro; Biodistribution; Gene delivery; Transfection; Polyethylene glycol; Biochemistry; Organic chemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002094896,0.0001275063,0.0001527262,0.00002307922,0.0000567037,0.00006034559,0.0001816482,0.0001306661,0.000003919223],"category_scores_gemma":[0.0001543098,0.0001273389,0.00003063395,0.00002594798,0.00009126848,0.00001169313,0.00006410196,0.00008431032,0.000005042547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001561729,"about_ca_system_score_gemma":0.00004671311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001417695,"about_ca_topic_score_gemma":0.0002264062,"domain_scores_codex":[0.9991906,0.00005843577,0.0001884517,0.0002254535,0.00007484984,0.0002622254],"domain_scores_gemma":[0.9994442,0.00004588151,0.00008370118,0.000321462,0.00004571903,0.00005896248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005160556,0.00004303,0.029243,0.000005809958,0.00001258743,0.00001364163,0.00007371334,0.000250108,0.969062,0.000008638475,0.0001158277,0.0006555964],"study_design_scores_gemma":[0.00168255,0.0001219894,0.01922185,0.00002535514,0.00001083943,0.000005880449,0.00004225305,0.002881448,0.9741847,0.00009869522,0.0015435,0.000180977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982334,0.0008798371,0.0001192357,0.000216806,0.00008842611,0.0001495354,0.00002497606,0.00001614991,0.0002716756],"genre_scores_gemma":[0.9982725,0.0008685315,0.0001553928,0.000477528,0.00006360903,0.000005496739,0.00001364868,0.00002777663,0.0001154921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01002115,"threshold_uncertainty_score":0.5192729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01091176760760776,"score_gpt":0.242997461761389,"score_spread":0.2320856941537812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}