{"id":"W2617842398","doi":"10.1007/s11883-017-0667-9","title":"Genetics of Triglycerides and the Risk of Atherosclerosis","year":2017,"lang":"en","type":"review","venue":"Current Atherosclerosis Reports","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Canadian Institutes of Health Research; Genome Canada; Heart and Stroke Foundation of Canada","keywords":"Mendelian randomization; PCSK9; Genetics; Apolipoprotein B; Genome-wide association study; Population; Genetic epidemiology; Medicine; Lipoprotein lipase; Hepatic lipase; Internal medicine; Bioinformatics; Lipoprotein; Biology; Endocrinology; Cholesterol; Gene; Single-nucleotide polymorphism; LDL receptor; Genetic variants; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001507529,0.0006950134,0.00460872,0.0002034959,0.0002044358,0.0000528735,0.0003652544,0.0003699143,0.00004614379],"category_scores_gemma":[0.001168656,0.0003934024,0.00176588,0.0002377383,0.001537375,0.00007555584,0.0003023254,0.0005587998,0.000004427501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003166702,"about_ca_system_score_gemma":0.0004380087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009096017,"about_ca_topic_score_gemma":0.000003467661,"domain_scores_codex":[0.995648,0.0003324518,0.002250061,0.0007233557,0.000666181,0.0003799337],"domain_scores_gemma":[0.9913715,0.0003638894,0.005423136,0.002393567,0.0002481471,0.0001997211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004681377,0.0002706277,0.006846031,0.01435756,0.0005980504,0.000001084192,0.0003313561,3.586084e-7,0.00001332254,0.00005897471,0.0003967383,0.9770791],"study_design_scores_gemma":[0.001974527,0.00009516106,0.006473612,0.01804922,0.01036813,0.00005681243,0.00002800005,0.000005090859,0.00004505237,0.0001174409,0.9624138,0.0003731441],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00645048,0.9894471,0.00001988943,0.00001406463,0.001459774,0.002105676,0.0001472605,0.00003265985,0.000323132],"genre_scores_gemma":[0.004787559,0.994276,0.0001224381,0.00000688775,0.0003027953,0.0001788978,0.00005547456,0.0001136242,0.0001563293],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9767059,"threshold_uncertainty_score":0.9998518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.134492121738641,"score_gpt":0.3855632787429618,"score_spread":0.2510711570043208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}