{"id":"W2617854290","doi":"10.1093/ndt/gfx170.mp393","title":"MP393LONG-TERM SAFETY AND EFFECTIVENESS OF ECULIZUMAB FOR PATIENTS WITH ATYPICAL HAEMOLYTIC URAEMIC SYNDROME: OUTCOMES FROM A PROSPECTIVE OBSERVATIONAL CLINICAL TRIAL","year":2017,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Hospital for Sick Children","funders":"","keywords":"Medicine; Eculizumab; Observational study; Atypical hemolytic uremic syndrome; Haemolytic-uraemic syndrome; Clinical trial; Intensive care medicine; Pediatrics; Internal medicine; Immunology; Antibody; Complement system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003197967,0.0005057195,0.001223403,0.0002402043,0.0002931469,0.0009946858,0.0004943202,0.0008530286,0.001756426],"category_scores_gemma":[0.003907321,0.0002533539,0.001866219,0.0005569596,0.0003206573,0.000794392,0.0004219261,0.00106013,0.00024842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003914245,"about_ca_system_score_gemma":0.00045486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003245386,"about_ca_topic_score_gemma":0.0004756491,"domain_scores_codex":[0.9984851,0.0006913702,0.0002296584,0.0002686834,0.0002220839,0.0001030572],"domain_scores_gemma":[0.9952847,0.0009753115,0.002631471,0.0003450929,0.0002429894,0.0005204052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.4304358,0.005671011,0.4902599,0.002274365,0.01884729,0.0007104923,0.0003271774,0.001109024,0.005100271,0.0001900037,0.001493567,0.04358114],"study_design_scores_gemma":[0.06349301,0.07521877,0.8416312,0.0003602633,0.01084119,0.001582533,0.000177478,0.002663479,0.001252317,0.0002923049,0.002403742,0.00008374501],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961009,0.002646776,0.0001503524,0.00007589904,0.00001535108,0.0001320284,0.0006094014,0.000004985992,0.0002643022],"genre_scores_gemma":[0.9973187,0.0008289928,0.0001952718,0.00009982072,0.00006448758,0.0001719351,0.001202966,0.000002123572,0.0001157811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003197967,"threshold_uncertainty_score":0.0169127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0356810443350838,"score_gpt":0.3186480741020331,"score_spread":0.2829670297669493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}