{"id":"W2617854290","doi":"10.1093/ndt/gfx170.mp393","title":"MP393LONG-TERM SAFETY AND EFFECTIVENESS OF ECULIZUMAB FOR PATIENTS WITH ATYPICAL HAEMOLYTIC URAEMIC SYNDROME: OUTCOMES FROM A PROSPECTIVE OBSERVATIONAL CLINICAL TRIAL","year":2017,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Hospital for Sick Children","funders":"","keywords":"Medicine; Eculizumab; Observational study; Atypical hemolytic uremic syndrome; Haemolytic-uraemic syndrome; Clinical trial; Intensive care medicine; Pediatrics; Internal medicine; Immunology; Antibody; Complement system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004463137,0.0002217553,0.000844441,0.00008349003,0.0003542143,0.0000212993,0.0002492463,0.0002710044,0.0001011608],"category_scores_gemma":[0.0002616124,0.0001786349,0.0002029595,0.00004056225,0.0005092571,0.000192704,0.00003130278,0.0001347073,0.00001018271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004150375,"about_ca_system_score_gemma":0.00007969281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006934535,"about_ca_topic_score_gemma":0.0001446745,"domain_scores_codex":[0.9978856,0.0006049401,0.0006895701,0.0005134417,0.00008163541,0.0002247955],"domain_scores_gemma":[0.9960558,0.002803345,0.0005407289,0.000390143,0.0001784108,0.00003154925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1733808,0.0004628612,0.8233885,0.0001009566,0.001369059,0.000003031134,0.0001045157,0.000004576291,0.0005333236,0.0002842121,0.00001193642,0.0003562159],"study_design_scores_gemma":[0.0986407,0.001461418,0.8976429,0.00008860305,0.00138831,0.00000654067,0.000007175795,0.000008648335,0.0002167211,0.0003594665,0.00001924387,0.0001603493],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993642,0.00005921395,0.001980321,0.00006948187,0.0004343372,0.002387438,0.001380686,0.00003069581,0.00001584857],"genre_scores_gemma":[0.9958891,0.00002752183,0.0001474583,0.00002988758,0.00002862589,0.0003099161,0.003538007,0.00001624292,0.00001328591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07474008,"threshold_uncertainty_score":0.7284518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0356810443350838,"score_gpt":0.3186480741020331,"score_spread":0.2829670297669493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}