{"id":"W2617857661","doi":"10.1111/acel.12619","title":"Transcription factors <scp>CEP</scp>‐1/p53 and <scp>CEH</scp>‐23 collaborate with <scp>AAK</scp>‐2/<scp>AMPK</scp> to modulate longevity in Caenorhabditis <i>elegans</i>.","year":2017,"lang":"en","type":"article","venue":"Aging Cell","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University; National Institute on Aging; National Institutes of Health; Harvard University","keywords":"Caenorhabditis elegans; Biology; AMPK; Transcription factor; Coactivator; Cell biology; Longevity; Mitochondrion; Genetics; Gene; Phosphorylation; Protein kinase A","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0008886036,0.00130163,0.001108636,0.0003736678,0.001013796,0.0009127557,0.001402811,0.0008514944,0.000005028755],"category_scores_gemma":[0.0009557964,0.001334263,0.000266284,0.0005087606,0.0005583435,0.0001392751,0.0005049597,0.000864203,0.00008774704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001456632,"about_ca_system_score_gemma":0.0003404374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001292003,"about_ca_topic_score_gemma":0.003080397,"domain_scores_codex":[0.9937071,0.0003408172,0.0009370072,0.00221003,0.0008089628,0.001996093],"domain_scores_gemma":[0.9953541,0.0003490199,0.0007294958,0.002133358,0.0005055832,0.0009284233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001092389,0.000464691,0.110521,0.0004677265,0.0002546809,0.0001710657,0.01331288,0.00368624,0.8545939,0.00003623537,0.01593753,0.0005431406],"study_design_scores_gemma":[0.003009419,0.0009492925,0.1333165,0.0002164605,0.0002726013,0.00006538067,0.003886557,0.0006584711,0.7436503,0.0002417228,0.1134263,0.0003071161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864456,0.002711379,0.004555302,0.0001433538,0.0009913158,0.001279513,0.0003573039,0.0001530624,0.003363169],"genre_scores_gemma":[0.9841973,0.001760248,0.001707599,0.0008251208,0.0005785277,0.00007042345,0.0004619947,0.0002950514,0.01010378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1109436,"threshold_uncertainty_score":0.9999735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01007746406211422,"score_gpt":0.2195327950581224,"score_spread":0.2094553309960082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}