{"id":"W2617857661","doi":"10.1111/acel.12619","title":"Transcription factors <scp>CEP</scp>‐1/p53 and <scp>CEH</scp>‐23 collaborate with <scp>AAK</scp>‐2/<scp>AMPK</scp> to modulate longevity in Caenorhabditis <i>elegans</i>.","year":2017,"lang":"en","type":"article","venue":"Aging Cell","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University; National Institute on Aging; National Institutes of Health; Harvard University","keywords":"Caenorhabditis elegans; Biology; AMPK; Transcription factor; Coactivator; Cell biology; Longevity; Mitochondrion; Genetics; Gene; Phosphorylation; Protein kinase A","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007966929,0.0004552445,0.000203942,0.0002523515,0.0002478678,0.0002659494,0.0001880235,0.0001783961,0.001031687],"category_scores_gemma":[0.0001074211,0.0001226724,0.0002977761,0.00009874041,0.0002648505,0.0001832119,0.0002885663,0.0004618871,0.000331145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004063179,"about_ca_system_score_gemma":0.000284278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001170133,"about_ca_topic_score_gemma":0.002616664,"domain_scores_codex":[0.999899,0.000005917708,0.000005508525,0.00003592458,0.00002911693,0.00002450082],"domain_scores_gemma":[0.9998996,0.00001078003,0.00003564269,0.00001107962,0.00001283998,0.00002996219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006251122,0.000009273545,0.0005083305,0.00002258572,0.00000511671,0.00009889339,0.000007951852,0.00005648996,0.9973617,0.00008420552,0.00007384865,0.001709068],"study_design_scores_gemma":[0.00001923394,0.0001563026,0.03343233,0.00000988545,0.00003362584,0.0004729514,0.00005010647,0.001825272,0.9591819,0.0001427075,0.004660994,0.00001463492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874981,0.003113804,0.005255327,0.0002009557,0.00007058594,0.00004363913,0.001079881,0.0002802551,0.002457334],"genre_scores_gemma":[0.9934742,0.0007455395,0.00244308,0.0001005225,0.00001289813,0.00003228704,0.001093905,0.00003246533,0.002065083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001170133,"threshold_uncertainty_score":0.003451347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01007746406211422,"score_gpt":0.2195327950581224,"score_spread":0.2094553309960082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}