{"id":"W2617943271","doi":"10.1007/s00280-008-0848-x","title":"Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand","year":2008,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Synthesis and pharmacology of benzodiazepine derivatives","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Identification (biology); Benzodiazepine; Ligand (biochemistry); Peripheral; Pharmacology; Chemistry; GABAA receptor; Receptor; Biology; Medicine; Biochemistry; Internal medicine; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001808369,0.0002918394,0.0002874556,0.0002076846,0.0001221332,0.0002665719,0.0002384583,0.0001828934,0.0006334486],"category_scores_gemma":[0.0001743092,0.0001321052,0.0001399699,0.0001679358,0.0001660665,0.0001888099,0.0001509092,0.0003741231,0.0004718762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002649915,"about_ca_system_score_gemma":0.0003584891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007945294,"about_ca_topic_score_gemma":0.001042588,"domain_scores_codex":[0.9999166,0.00001693835,0.000006132138,0.00001369972,0.00002639814,0.0000203307],"domain_scores_gemma":[0.9999341,0.000007927342,0.00001779557,0.000007701329,0.00001105774,0.00002146629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002099126,0.000110824,0.0004404409,0.0000447319,0.000006203434,0.0001195201,0.0000274125,0.0004341241,0.9902322,0.0001667417,0.0001101622,0.008097569],"study_design_scores_gemma":[0.000178701,0.002634132,0.006644003,0.00001154434,0.00004530859,0.002224141,0.00004371282,0.002402225,0.9731727,0.0001040199,0.01251927,0.00002027503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871613,0.004031877,0.005538283,0.0001859718,0.00001551657,0.00008182839,0.0004684041,0.00005038748,0.002466369],"genre_scores_gemma":[0.9862364,0.003839423,0.004517735,0.00009292387,0.00001379297,0.00004700394,0.001770516,0.00001561707,0.003466594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007945294,"threshold_uncertainty_score":0.002119124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0221733434168732,"score_gpt":0.289562908502084,"score_spread":0.2673895650852108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}