{"id":"W2618122943","doi":"10.1038/ncomms15382","title":"Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants","year":2017,"lang":"en","type":"review","venue":"Nature Communications","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":400,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Toronto Western Hospital; University of Toronto","funders":"National Center for Research Resources; European Regional Development Fund; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Medical Research Council; National Institutes of Health; Tartu Ülikool; Heinz Nixdorf Stiftung; Deutsche Forschungsgemeinschaft; Exzellenzclusters Entzündungsforschung; National Research Foundation; King's College London; Psoriasis Association; National Human Genome Research Institute; Wellcome Trust; National Psoriasis Foundation; Helene Morgan Babcock and Alfred Babcock Memorial Scholarship Trust; A. Alfred Taubman Medical Research Institute; Dermatology Foundation; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Arthritis National Research Foundation; U.S. Department of Veterans Affairs; Foundation for the National Institutes of Health","keywords":"Psoriasis; Genome-wide association study; Genetic architecture; Heritability; Genetics; Genetic association; Biology; Meta-analysis; Computational biology; Medicine; Quantitative trait locus; Single-nucleotide polymorphism; Immunology; Gene; Genotype; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004628494,0.0009345877,0.003374432,0.002528034,0.000190779,0.001216681,0.001086409,0.0008170584,0.002049815],"category_scores_gemma":[0.006529298,0.0003877161,0.004507822,0.003438873,0.0003216257,0.0004154765,0.0006209476,0.0008795207,0.0002003823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005497469,"about_ca_system_score_gemma":0.0008356678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001105259,"about_ca_topic_score_gemma":0.002463223,"domain_scores_codex":[0.998092,0.0009846413,0.0001959409,0.000340686,0.0003150245,0.0000716643],"domain_scores_gemma":[0.993996,0.004565037,0.0006999569,0.0002631343,0.000372958,0.0001029704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.003446253,0.00008529254,0.08707245,0.06201113,0.2409281,0.001306734,0.0001376843,0.00415143,0.003469199,0.0028114,0.0109187,0.5836617],"study_design_scores_gemma":[0.001409684,0.001169228,0.3060902,0.01721626,0.5370057,0.006306406,0.0002888808,0.005872684,0.003583987,0.01891682,0.1018977,0.0002422304],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00721397,0.9899195,0.001527,0.0005392854,0.0001109271,0.00001878425,0.0002768007,0.00003101403,0.0003626607],"genre_scores_gemma":[0.249548,0.7449161,0.002905084,0.0006816636,0.0004965204,0.00007810852,0.0009495568,0.00003817328,0.0003867495],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004628494,"threshold_uncertainty_score":0.02447814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1216175602596136,"score_gpt":0.3777229581284424,"score_spread":0.2561053978688288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}