{"id":"W2618144711","doi":"10.1182/blood.v128.22.402.402","title":"Effects of AG-348, a Pyruvate Kinase Activator, on Anemia and Hemolysis in Patients with Pyruvate Kinase Deficiency: Data from the DRIVE PK Study","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Pyruvate kinase deficiency; Pyruvate kinase; Medicine; Adverse effect; Internal medicine; Hemolysis; Anemia; Endocrinology; Gastroenterology; Glycolysis; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001279374,0.0001991494,0.0003793601,0.00008490621,0.00006318573,0.000007313495,0.0001889182,0.00007444873,0.00003424204],"category_scores_gemma":[0.0002734279,0.000098039,0.00002856293,0.0002495568,0.0001329082,0.00009009923,0.0001598567,0.0001575165,0.00001711459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002093731,"about_ca_system_score_gemma":0.00005723382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002384287,"about_ca_topic_score_gemma":0.00008808188,"domain_scores_codex":[0.9986125,0.0001617851,0.000224721,0.0005133953,0.0002689347,0.0002187243],"domain_scores_gemma":[0.9983019,0.0005334985,0.0001432998,0.0008671223,0.00006480387,0.00008934569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002317787,0.005818298,0.8621519,0.00007327931,0.0001552762,0.0001210222,0.0008984958,7.329372e-7,0.1251331,0.00001207821,0.0001493974,0.003168587],"study_design_scores_gemma":[0.019138,0.003312348,0.9397703,0.0003048021,0.0004075305,8.58469e-7,0.0001999722,0.000004769832,0.03662287,0.00003414717,0.00006375192,0.0001405712],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998623,0.0001239348,0.000008089621,0.0001469393,0.00007946431,0.00083433,0.00009159926,0.00002551639,0.00006709061],"genre_scores_gemma":[0.9994014,0.00003573378,0.00005628676,0.000311059,0.00005206932,0.00002772758,0.00006252799,0.00002136323,0.00003185543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08851025,"threshold_uncertainty_score":0.3997914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164294693058558,"score_gpt":0.2319990370272559,"score_spread":0.2203560900966704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}