{"id":"W2618230221","doi":"10.1016/j.ceca.2017.05.015","title":"Endoplasmic reticulum chaperones tweak the mitochondrial calcium rheostat to control metabolism and cell death","year":2017,"lang":"en","type":"review","venue":"Cell Calcium","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Calnexin; Endoplasmic reticulum; Calreticulin; Protein disulfide-isomerase; Cell biology; Unfolded protein response; Chaperone (clinical); Mitochondrion; Protein folding; Biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004951797,0.0007971362,0.001264535,0.001033677,0.0002828185,0.001206465,0.00103022,0.001151746,0.00241158],"category_scores_gemma":[0.0005772623,0.0002251521,0.0002888479,0.001166761,0.0007096106,0.001297265,0.0009708349,0.002381082,0.002261022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006075288,"about_ca_system_score_gemma":0.0008036543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004987314,"about_ca_topic_score_gemma":0.001474929,"domain_scores_codex":[0.9998615,0.00001706999,0.00001868563,0.00002062848,0.00005846964,0.0000235619],"domain_scores_gemma":[0.9998123,0.00005055516,0.00003388214,0.000008535025,0.00006160363,0.00003313358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002349037,0.00006204278,0.0001772084,0.008458371,0.0001043546,0.0003464664,0.00006473999,0.0003790059,0.009034649,0.009838817,0.07211346,0.899186],"study_design_scores_gemma":[0.00002719236,0.00004240969,0.0003822318,0.0006483883,0.00006143488,0.0004377479,0.00004197673,0.00007418712,0.00122929,0.002443729,0.9945957,0.00001571086],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002558501,0.9966078,0.000349982,0.0008374401,0.0007476211,0.000005957043,0.00003386075,0.00002281607,0.001138673],"genre_scores_gemma":[0.001758744,0.9953691,0.0002657438,0.0004754492,0.0004554509,0.000008145465,0.00005732671,0.000003738749,0.001606266],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00241158,"threshold_uncertainty_score":0.008067548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03979943346603765,"score_gpt":0.3175234600666931,"score_spread":0.2777240266006555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}