{"id":"W2618292058","doi":"10.1073/pnas.1614943114","title":"KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients","year":2017,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Medical Research Council; Directorate for Biological Sciences; Biotechnology and Biological Sciences Research Council; Rosetrees Trust; National Institutes of Health; Cancer Research UK; Wellcome Trust; Alzheimer Forschung Initiative; CHDI Foundation","keywords":"KEAP1; Proinflammatory cytokine; Transcription factor; Cell biology; Signal transduction; Biology; Signal transducing adaptor protein; Inducer; Cell signaling; Regulator; Chemistry; Immunology; Biochemistry; Gene; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007797885,0.0001455725,0.0002014528,0.0001463643,0.00009920701,0.0001161132,0.00006716503,0.000221459,0.0009887711],"category_scores_gemma":[0.00006496935,0.00007364364,0.0001348525,0.00009625594,0.0001201791,0.00005652321,0.00008277841,0.0002227419,0.0001687084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001008468,"about_ca_system_score_gemma":0.00007916333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003517379,"about_ca_topic_score_gemma":0.0006167887,"domain_scores_codex":[0.999964,0.000006441924,0.000005317916,0.000009681177,0.000006899118,0.000007655959],"domain_scores_gemma":[0.9999752,0.000003899432,0.000006692199,0.000002729797,0.000003938488,0.000007601241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002462119,0.00003146479,0.0009679362,0.00002309335,0.00001091608,0.0002437648,0.00002585585,0.00002468176,0.996886,0.00002092697,0.000027078,0.001492122],"study_design_scores_gemma":[0.0001157979,0.001998483,0.08366454,0.00001021684,0.00009470112,0.003247122,0.0001327982,0.0007499882,0.9072713,0.0001132614,0.002592223,0.000009475799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990977,0.000277003,0.0002535993,0.00003389983,0.000004510796,0.000009066187,0.0001359294,0.000008730341,0.0001795363],"genre_scores_gemma":[0.9987081,0.0001893598,0.0002600815,0.00003880187,0.000002385762,0.000009997194,0.0003179828,0.00000220226,0.0004711101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009887711,"threshold_uncertainty_score":0.003307819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04370632409521975,"score_gpt":0.2929392628296551,"score_spread":0.2492329387344354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}