{"id":"W2618292946","doi":"10.1038/leu.2017.159","title":"A phase 1b/2b multicenter study of oral panobinostat plus azacitidine in adults with MDS, CMML or AML with ⩽30% blasts","year":2017,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta Hospital; Alberta Hospital Edmonton; Princess Margaret Cancer Centre","funders":"Novartis Pharmaceuticals Corporation","keywords":"Medicine; Internal medicine; Azacitidine; Panobinostat; Chronic myelomonocytic leukemia; Neutropenia; Myelodysplastic syndromes; International Prognostic Scoring System; Regimen; Adverse effect; Gastroenterology; Phases of clinical research; Oncology; Bone marrow; Clinical trial; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003408941,0.0004428209,0.000931402,0.0003165547,0.0001879644,0.00007442786,0.0005704046,0.0001585376,0.0002771971],"category_scores_gemma":[0.0003095257,0.0002750223,0.00006155071,0.0003123292,0.0004355376,0.0003453325,0.0002706737,0.0008101289,0.00007413157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001632435,"about_ca_system_score_gemma":0.001597788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005776031,"about_ca_topic_score_gemma":0.007233398,"domain_scores_codex":[0.9968117,0.0001170289,0.0005584277,0.0007421959,0.0009538296,0.0008167792],"domain_scores_gemma":[0.9972194,0.0001290196,0.0003545578,0.001563729,0.0003565994,0.0003767278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2809848,0.02083682,0.5698714,0.002425789,0.001793882,0.03182904,0.03807893,0.0003105296,0.007802447,0.00003871812,0.007040793,0.03898684],"study_design_scores_gemma":[0.627277,0.04992841,0.2644282,0.004500127,0.000589834,0.000393004,0.01687878,0.01855065,0.01440853,0.000005674607,0.001853525,0.001186304],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955915,0.00002971798,0.00005620779,0.000284564,0.00005848892,0.002584677,0.00004407158,0.00006502127,0.001285775],"genre_scores_gemma":[0.9964307,0.00003844329,0.0009879087,0.0001767514,0.0001138174,0.000173663,0.0000453626,0.00009908457,0.001934282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3462921,"threshold_uncertainty_score":0.9999702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02869366442021905,"score_gpt":0.334618221240216,"score_spread":0.305924556819997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}