{"id":"W2618381598","doi":"10.1038/leu.2017.171","title":"Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia","year":2017,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Cancer Society Research Institute; Deutsche Krebshilfe; Terry Fox Research Institute; Deutsche Forschungsgemeinschaft","keywords":"RUNX1; Biology; Myeloid; Myelopoiesis; Epigenomics; Cancer research; Transcription factor; Epigenetics; Myeloid leukemia; Cellular differentiation; Haematopoiesis; DNA methylation; Cell biology; Molecular biology; Stem cell; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009585816,0.0004724967,0.0008775928,0.0004438126,0.0005243765,0.0002032298,0.001076558,0.0005041042,0.0001651894],"category_scores_gemma":[0.0004390549,0.0004441915,0.0002367996,0.0002541237,0.0002418061,0.0004388855,0.0004829533,0.00164148,0.0009039031],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006183795,"about_ca_system_score_gemma":0.002399389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00214942,"about_ca_topic_score_gemma":0.0002787982,"domain_scores_codex":[0.9962881,0.0000967919,0.0007314706,0.0009488817,0.0006807737,0.00125394],"domain_scores_gemma":[0.9965343,0.0001371354,0.0003046828,0.002385298,0.0001536605,0.0004849269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007274513,0.00007035208,0.01141839,0.0001200808,0.0002028201,0.003462743,0.0009074773,0.0001552126,0.9553342,0.0004992919,0.001176893,0.02592503],"study_design_scores_gemma":[0.02568015,0.001001655,0.1686941,0.001455395,0.0005281547,0.00171724,0.0006498672,0.08723781,0.6950837,0.002411061,0.01326875,0.002272186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800705,0.0001205847,0.0004044086,0.001779654,0.0003498356,0.0008737011,0.00001775553,0.0001446507,0.01623886],"genre_scores_gemma":[0.9923412,0.0004409912,0.002658489,0.0005789355,0.0005645982,0.00006679873,0.00004377833,0.000134123,0.003171089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2602506,"threshold_uncertainty_score":0.999874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03526885580970547,"score_gpt":0.3171289168936529,"score_spread":0.2818600610839474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}