{"id":"W2618381598","doi":"10.1038/leu.2017.171","title":"Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia","year":2017,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Cancer Society Research Institute; Deutsche Krebshilfe; Terry Fox Research Institute; Deutsche Forschungsgemeinschaft","keywords":"RUNX1; Biology; Myeloid; Myelopoiesis; Epigenomics; Cancer research; Transcription factor; Epigenetics; Myeloid leukemia; Cellular differentiation; Haematopoiesis; DNA methylation; Cell biology; Molecular biology; Stem cell; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008977603,0.0001355249,0.0001635239,0.0003148612,0.0001154189,0.0001306514,0.0001387947,0.0001793574,0.0009465448],"category_scores_gemma":[0.00009519589,0.00008941266,0.0001265641,0.0001433607,0.000167737,0.00008332511,0.0001157628,0.0001852537,0.000146874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002227489,"about_ca_system_score_gemma":0.00009671819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006805495,"about_ca_topic_score_gemma":0.0008276859,"domain_scores_codex":[0.9999292,0.00001632629,0.000006748224,0.00001700266,0.00001591126,0.00001478901],"domain_scores_gemma":[0.9999508,0.00001058935,0.00001341905,0.000008226934,0.000004886724,0.00001203135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002953821,0.00001761379,0.0004635142,0.00001628701,0.000003849346,0.00005813579,0.0000147816,0.00004700439,0.9980074,0.00005453914,0.00001085809,0.001010659],"study_design_scores_gemma":[0.00002484934,0.0004216818,0.01758911,0.000002894136,0.00001736846,0.0004457688,0.00003823757,0.0005326807,0.9795728,0.0001067231,0.001243354,0.000004517272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975801,0.0009099871,0.0008185355,0.00002185375,0.000006451473,0.00001303854,0.0002101023,0.00003060285,0.000409273],"genre_scores_gemma":[0.9983689,0.0002408627,0.0004841697,0.00001173844,0.000001296798,0.000009861113,0.0001681857,0.00000524522,0.0007098613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009465448,"threshold_uncertainty_score":0.003166556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03526885580970547,"score_gpt":0.3171289168936529,"score_spread":0.2818600610839474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}