{"id":"W2618433710","doi":"10.1093/neuonc/nox083.239","title":"TRTH-29. CONTEXT-SPECIFIC TUMOR SUPPRESSIVE FUNCTION OF THE CANONICAL WNT PATHWAY IN PEDIATRIC MEDULLOBLASTOMA HIGHLIGHTS A THERAPEUTIC STRATEGY FOR TREATMENT-REFRACTORY SUBGROUPS","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Wnt signaling pathway; Medulloblastoma; Cancer research; In vivo; Biology; SOX2; Medicine; Signal transduction; Cell biology; Transcription factor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116046,0.0002001714,0.0002332719,0.0001599734,0.0001191541,0.0002190182,0.0002139079,0.0001389846,0.002058415],"category_scores_gemma":[0.00007324702,0.00008697674,0.0002213575,0.0001180418,0.0001451537,0.0001151499,0.0001565327,0.0005208684,0.0005229525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002841593,"about_ca_system_score_gemma":0.0003443445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001134119,"about_ca_topic_score_gemma":0.003089781,"domain_scores_codex":[0.9999341,0.000009572474,0.00000680435,0.00001301213,0.00001770079,0.000018873],"domain_scores_gemma":[0.9999611,0.000004223069,0.0000107482,0.000006360076,0.000003273812,0.0000143419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002597155,0.00009538506,0.0007850401,0.00008100144,0.00001162777,0.0002680357,0.00002258397,0.0003133332,0.9845479,0.0004093829,0.0002793669,0.01292662],"study_design_scores_gemma":[0.0001335507,0.002289206,0.01240628,0.00002118499,0.00008782734,0.003291803,0.00008017984,0.001903479,0.9577448,0.0001849775,0.02184746,0.000009184115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881604,0.003491019,0.002973346,0.0002323148,0.00004378507,0.00008876397,0.0007051651,0.0001850388,0.004120219],"genre_scores_gemma":[0.9917632,0.002074587,0.002206584,0.00006699848,0.00001345078,0.00004821745,0.0009711393,0.0000394836,0.002816296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002058415,"threshold_uncertainty_score":0.006886065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03255406136176563,"score_gpt":0.308984839351115,"score_spread":0.2764307779893493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}