{"id":"W2618495552","doi":"10.1016/j.jaut.2017.05.006","title":"MicroRNA-146a governs fibroblast activation and joint pathology in arthritis","year":2017,"lang":"en","type":"article","venue":"Journal of Autoimmunity","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Seventh Framework Programme; Innovative Medicines Initiative; Providence Health Care; Austrian Science Fund; National Institute of Allergy and Infectious Diseases; European Commission; European Federation of Pharmaceutical Industries and Associations","keywords":"Arthritis; RANKL; Inflammation; Inflammatory arthritis; Osteoprotegerin; Cancer research; Immunology; Tumor necrosis factor alpha; Mesenchymal stem cell; Regulator; Medicine; Synovitis; Cell biology; Biology; Pathology; Receptor; Activator (genetics); Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003742087,0.00008406107,0.0001595093,0.00005517576,0.0001315856,0.00004950128,0.0001502942,0.0001141049,0.0000137502],"category_scores_gemma":[0.0003703216,0.0000824825,0.00006293765,0.00001808507,0.0001115513,0.00002245295,0.0001323921,0.0001714296,0.000001288268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003220456,"about_ca_system_score_gemma":0.00007716164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003673349,"about_ca_topic_score_gemma":0.00004281248,"domain_scores_codex":[0.999329,0.00009328009,0.0002962429,0.0000907423,0.00007951359,0.0001112788],"domain_scores_gemma":[0.9989766,0.000009030825,0.0005600912,0.000311304,0.00009906599,0.00004390398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008565257,0.0000564602,0.008088182,0.00001271566,0.00001737053,0.00001528488,0.00006190006,0.0000256885,0.9858485,0.00001830707,0.0002118028,0.00555815],"study_design_scores_gemma":[0.0007620048,0.0001380569,0.7504573,0.0001663648,0.000004085858,0.0001715698,0.00003668989,0.00001818482,0.2468636,0.0001804702,0.001132607,0.00006905883],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985455,0.0005395428,0.0002294796,0.0003738131,0.00006512195,0.00005844291,0.000007419914,0.00000161133,0.0001790324],"genre_scores_gemma":[0.998918,0.0004031089,0.0004832419,0.00004241202,0.00009007945,9.453732e-7,0.000008294383,0.000008939283,0.0000450032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7423691,"threshold_uncertainty_score":0.3363539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01370311037342765,"score_gpt":0.2512319009778819,"score_spread":0.2375287906044543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}