{"id":"W2618919723","doi":"10.1093/ndt/gfx162.mp092","title":"MP092APABETALONE, A BROMODOMAIN AND EXTRATERMINAL PROTEIN INHIBITOR, DECREASES KEY FACTORS IN VASCULAR CALCIFICATION IN VITRO AND IN CLINICAL TRIALS","year":2017,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Bromodomain; Medicine; In vitro; Calcification; Clinical trial; Pharmacology; Internal medicine; Biochemistry; Epigenetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004990032,0.0004574858,0.0004947133,0.0003336495,0.0001154668,0.0004906165,0.0002820507,0.0003739756,0.004661588],"category_scores_gemma":[0.0003733087,0.0001784398,0.0003751354,0.0002285915,0.0002040198,0.0002155894,0.0001059111,0.0009374985,0.0007098736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002506715,"about_ca_system_score_gemma":0.0002995461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003336371,"about_ca_topic_score_gemma":0.001213927,"domain_scores_codex":[0.9998355,0.00004664393,0.00001177327,0.00002817076,0.00005310774,0.00002468308],"domain_scores_gemma":[0.99983,0.00004076641,0.00005631315,0.00001100715,0.00001905043,0.00004284986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.05418774,0.004247734,0.00237335,0.002604066,0.000795202,0.0002023241,0.00009965701,0.0006902789,0.7190688,0.0002589597,0.008037045,0.2074348],"study_design_scores_gemma":[0.09967715,0.2077451,0.09183648,0.0005714617,0.002246092,0.003177393,0.0001712571,0.004006634,0.4933622,0.0006777441,0.09641576,0.0001127183],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9141579,0.06813657,0.002157808,0.001275959,0.0004070018,0.0005744908,0.003153043,0.0008080808,0.009329065],"genre_scores_gemma":[0.9612355,0.02110616,0.00318018,0.0006620826,0.0001999479,0.0004823276,0.003227629,0.00006239792,0.009843801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004661588,"threshold_uncertainty_score":0.01559454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05415687416785205,"score_gpt":0.3519748784624162,"score_spread":0.2978180042945642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}