{"id":"W2619003201","doi":"10.1038/s41588-018-0084-1","title":"Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes","year":2018,"lang":"en","type":"review","venue":"Nature Genetics","topic":"AI in cancer detection","field":"Computer Science","cited_by":470,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University and Génome Québec Innovation Centre; Université de Sherbrooke","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; NIHR Cambridge Biomedical Research Centre; Helmholtz Zentrum München; Korea Centers for Disease Control and Prevention; Korea National Institute of Health; National Center for Advancing Translational Sciences; Medical Research Council; Münchner Zentrum für Gesundheitswissenschaften; Erasmus Medisch Centrum; Genentech; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Centers for Disease Control and Prevention; Regeneron Pharmaceuticals; National Institutes of Health; Hjartavernd; Novo Nordisk Fonden; Eli Lilly and Company; Lundbeckfonden; ZonMw; British Heart Foundation; European Commission; Steno Diabetes Center Copenhagen; Wellcome Trust; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; GlaxoSmithKline; Pfizer; Incyte; Yale University","keywords":"Biology; Computational biology; Identification (biology); Coding (social sciences); Refining (metallurgy); Type 2 diabetes; Genetics; Diabetes mellitus; Statistics; Endocrinology; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009233176,0.0002780178,0.0006209395,0.0001851499,0.0001120603,0.0001406846,0.00165048,0.0006375229,0.000006722819],"category_scores_gemma":[0.0006110623,0.0002080196,0.0001348749,0.001946053,0.00006414227,0.0001867847,0.0003945365,0.0009891066,0.00001931108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001666636,"about_ca_system_score_gemma":0.0003097311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006249744,"about_ca_topic_score_gemma":0.000007087926,"domain_scores_codex":[0.9977183,0.0002857908,0.0007767499,0.0005599697,0.0003733066,0.0002859115],"domain_scores_gemma":[0.9970704,0.0005060299,0.0009857613,0.001137201,0.0002768307,0.00002381317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00000133409,0.00002380079,0.00004158022,0.003652298,0.0001187201,0.000004056471,0.0006783212,0.0001057116,0.00009808018,0.0007251492,0.002051448,0.9924995],"study_design_scores_gemma":[0.00006913795,0.00003340556,0.00006594674,0.003925765,0.00007967278,0.000008749255,0.000005665936,0.003446584,0.000827429,0.0009086941,0.990361,0.0002678917],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004560175,0.9618841,0.03457174,0.00007322823,0.002892374,0.0003270837,0.00001179778,0.0000550868,0.000138954],"genre_scores_gemma":[0.00121949,0.9652811,0.03288934,0.00006394646,0.0003982146,0.00003458099,0.00004359787,0.00003307422,0.00003664456],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9922316,"threshold_uncertainty_score":0.8482792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05926589266483752,"score_gpt":0.344572619758391,"score_spread":0.2853067270935535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}