{"id":"W2619003201","doi":"10.1038/s41588-018-0084-1","title":"Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes","year":2018,"lang":"en","type":"review","venue":"Nature Genetics","topic":"AI in cancer detection","field":"Computer Science","cited_by":470,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University and Génome Québec Innovation Centre; Université de Sherbrooke","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; NIHR Cambridge Biomedical Research Centre; Helmholtz Zentrum München; Korea Centers for Disease Control and Prevention; Korea National Institute of Health; National Center for Advancing Translational Sciences; Medical Research Council; Münchner Zentrum für Gesundheitswissenschaften; Erasmus Medisch Centrum; Genentech; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Centers for Disease Control and Prevention; Regeneron Pharmaceuticals; National Institutes of Health; Hjartavernd; Novo Nordisk Fonden; Eli Lilly and Company; Lundbeckfonden; ZonMw; British Heart Foundation; European Commission; Steno Diabetes Center Copenhagen; Wellcome Trust; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; GlaxoSmithKline; Pfizer; Incyte; Yale University","keywords":"Biology; Computational biology; Identification (biology); Coding (social sciences); Refining (metallurgy); Type 2 diabetes; Genetics; Diabetes mellitus; Statistics; Endocrinology; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003802395,0.0008703828,0.002229568,0.001858538,0.0001699943,0.001531273,0.00201325,0.001637889,0.001794749],"category_scores_gemma":[0.008438307,0.0003642303,0.001174605,0.001593683,0.0007879505,0.0009180895,0.0007722136,0.001972275,0.0009372784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007285255,"about_ca_system_score_gemma":0.001074557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001782522,"about_ca_topic_score_gemma":0.002183815,"domain_scores_codex":[0.9987379,0.0003810785,0.0001279368,0.0003092814,0.0003658565,0.00007796922],"domain_scores_gemma":[0.9939468,0.004946743,0.0003059819,0.0001522216,0.0005848867,0.00006339395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001876608,0.00003862317,0.003396772,0.00494279,0.0004588682,0.0001726094,0.00003649779,0.0008574137,0.001347539,0.003675304,0.00700772,0.9778782],"study_design_scores_gemma":[0.0002374842,0.0006708839,0.03193295,0.01632956,0.005549632,0.009007976,0.0002781799,0.01002598,0.01548077,0.04978851,0.860426,0.0002720937],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00140476,0.9930174,0.003297054,0.0008556993,0.0002381343,0.000008397345,0.0001288774,0.00003928102,0.001010474],"genre_scores_gemma":[0.02996184,0.9612458,0.00495993,0.001795637,0.0005933986,0.00002668931,0.0004222068,0.00002836236,0.0009660954],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003802395,"threshold_uncertainty_score":0.02010918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05926589266483752,"score_gpt":0.344572619758391,"score_spread":0.2853067270935535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}