{"id":"W2619242535","doi":"10.1021/acs.biochem.7b00293","title":"Binding of Copper and Cisplatin to Atox1 Is Mediated by Glutathione through the Formation of Metal–Sulfur Clusters","year":2017,"lang":"en","type":"article","venue":"Biochemistry","topic":"Trace Elements in Health","field":"Nursing","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Division of Advanced Cyberinfrastructure; Basic Energy Sciences; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Saskatchewan Health Research Foundation; U.S. Department of Energy; Office of Science; National Science Foundation","keywords":"Glutathione; Copper; Chemistry; Cisplatin; Sulfur metabolism; Platinum; Sulfur; Chaperone (clinical); Biochemistry; Metabolism; Enzyme; Chemotherapy; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001432189,0.0003252014,0.0002436625,0.0001952191,0.000287665,0.0002359378,0.0002962174,0.0003487114,0.001432299],"category_scores_gemma":[0.0002190081,0.0001814439,0.0002866649,0.0001877156,0.000232137,0.0002251815,0.000271726,0.0003480951,0.0003143229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002639822,"about_ca_system_score_gemma":0.0001537159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006769658,"about_ca_topic_score_gemma":0.0006345208,"domain_scores_codex":[0.9998001,0.00004262385,0.000008065887,0.00004860773,0.00005964877,0.00004093165],"domain_scores_gemma":[0.9998901,0.00001978873,0.00003781721,0.000009385713,0.00001710757,0.00002582483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007258131,0.00002077346,0.000640558,0.00003677838,0.00001322418,0.00006458255,0.00005276677,0.00007763939,0.9974898,0.0001125178,0.00007733522,0.001341476],"study_design_scores_gemma":[0.000005721511,0.0002684313,0.006359812,0.000004920937,0.000009492757,0.0002021618,0.00004782232,0.000913463,0.9898797,0.00007821217,0.002223607,0.000006826645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907732,0.001200751,0.005943329,0.0001359053,0.00002359994,0.00003176491,0.0001016901,0.0000583843,0.001731374],"genre_scores_gemma":[0.9931322,0.0004833462,0.0030378,0.00005442153,0.000007577455,0.00002400972,0.0001672979,0.00001377894,0.003079615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001432299,"threshold_uncertainty_score":0.004791498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02483881390755718,"score_gpt":0.3163650449059297,"score_spread":0.2915262309983725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}