{"id":"W2619280991","doi":"10.1016/j.etp.2017.05.005","title":"Attenuation of thioacetamide-induced hepatocellular injury by short-term repeated injections associated with down-regulation of metabolic enzymes and relationship with MHC class II-presenting cells","year":2017,"lang":"en","type":"article","venue":"Experimental and Toxicologic Pathology","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Japan Society for the Promotion of Science","keywords":"Thioacetamide; Liver injury; Centrilobular necrosis; Alanine transaminase; TLR4; Inflammation; Necrosis; Internal medicine; Endocrinology; Biology; Immunology; Chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001355336,0.0005863785,0.0003623732,0.0003437277,0.0001892343,0.0003150852,0.0002910383,0.0002956517,0.001670917],"category_scores_gemma":[0.0001849048,0.0001715285,0.0003175148,0.0002052115,0.0005815496,0.0004354272,0.0001465688,0.001198059,0.0003409979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002526543,"about_ca_system_score_gemma":0.0003292327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004845305,"about_ca_topic_score_gemma":0.000846663,"domain_scores_codex":[0.9998622,0.00001983636,0.00001081074,0.00003082634,0.00002636536,0.00004987926],"domain_scores_gemma":[0.9997303,0.00003122405,0.000087853,0.00004856495,0.00002640325,0.00007555864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001018774,0.0001642338,0.0002046807,0.00001998496,0.00000607013,0.00006493667,0.00001872331,0.00003576989,0.9968629,0.00007391668,0.00002161759,0.00150836],"study_design_scores_gemma":[0.00005318702,0.002013394,0.004660535,0.000003807808,0.00002633564,0.0001860351,0.00004067274,0.0005227629,0.9919499,0.00005465167,0.0004825296,0.000006138944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965953,0.0007821458,0.001662142,0.00008382438,0.00005467655,0.0000276707,0.0001376562,0.00009321999,0.0005633871],"genre_scores_gemma":[0.9953128,0.0004070778,0.00123232,0.00002686418,0.00003079068,0.00005069297,0.0001962379,0.00001791878,0.002725211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001670917,"threshold_uncertainty_score":0.005589783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1018656741306844,"score_gpt":0.3767533989397173,"score_spread":0.2748877248090328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}