{"id":"W2619400894","doi":"10.1038/s41598-017-02927-2","title":"Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Center for Advancing Translational Sciences; National Institute of Child Health and Human Development; Canadian Institutes of Health Research; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canada Research Chairs; National Institutes of Health; Children's Hospital Foundation; Rare Diseases Clinical Research Network; Rare Disease Foundation; BC Children's Hospital","keywords":"Arginase; CRISPR; Urea cycle; Genome editing; Biology; Induced pluripotent stem cell; Exon; Gene knockin; Phenotype; Locus (genetics); Gene; Cell biology; Cas9; Loss function; Cancer research; Genetics; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008530071,0.0008023363,0.0004584643,0.0008509978,0.0003865582,0.0006086639,0.001181465,0.00163862,0.005264005],"category_scores_gemma":[0.0004095796,0.0004597187,0.0006502901,0.0002419776,0.0006271098,0.0005962973,0.0005273821,0.002189206,0.001652362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004307827,"about_ca_system_score_gemma":0.0005448898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000317702,"about_ca_topic_score_gemma":0.000503812,"domain_scores_codex":[0.9994408,0.0001189028,0.00006487979,0.0001208989,0.0001842906,0.00007010676],"domain_scores_gemma":[0.9993935,0.0001163516,0.000199939,0.00009811499,0.00006004689,0.0001320813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001532171,0.0001392851,0.0000932496,0.0001220493,0.00001372147,0.0003078202,0.00004126939,0.0003142499,0.9915576,0.002926262,0.0004196271,0.003911672],"study_design_scores_gemma":[0.0001829084,0.001253389,0.0006522021,0.00006915571,0.00005318305,0.002024799,0.0000314088,0.003130832,0.9555794,0.000536093,0.0364642,0.00002241183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6331317,0.005690362,0.3294749,0.002647653,0.00204132,0.002248286,0.005902566,0.003838449,0.0150248],"genre_scores_gemma":[0.8068395,0.003860803,0.1588905,0.0004736138,0.0001491239,0.001331321,0.002724583,0.000551705,0.0251788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005264005,"threshold_uncertainty_score":0.01760989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02430628456038942,"score_gpt":0.3079653686488158,"score_spread":0.2836590840884264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}