{"id":"W2619565046","doi":"10.1126/science.aai9383","title":"Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women","year":2017,"lang":"en","type":"article","venue":"Science","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":416,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"Canadian Institutes of Health Research; Public Health Agency; Department of Science and Technology, Ministry of Science and Technology, India; University of Washington; National Research Foundation; Public Health Agency of Canada; National Institute of Allergy and Infectious Diseases; Manitoba Health Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; United States Agency for International Development","keywords":"Microbicide; Bacterial vaginosis; Gardnerella vaginalis; Lactobacillus; Microbicides for sexually transmitted diseases; Microbiology; Bacteria; Anaerobic bacteria; Tenofovir; Lactobacillus crispatus; Human immunodeficiency virus (HIV); Vagina; Medicine; Biology; Virology; Population; Surgery; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00142298,0.0001126082,0.0001637988,0.0003337503,0.000971209,0.0001649367,0.0011936,0.00006814161,0.0005225345],"category_scores_gemma":[0.001007275,0.00009746101,0.00002655055,0.0003248566,0.002805632,0.0005387664,0.0003570813,0.0003676893,0.001343254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002722836,"about_ca_system_score_gemma":0.0003194687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002149594,"about_ca_topic_score_gemma":0.00002166796,"domain_scores_codex":[0.9983799,0.00009042549,0.0001612124,0.0005660599,0.00006762637,0.0007347508],"domain_scores_gemma":[0.9986406,0.00006354741,0.00009064638,0.00104324,0.0001179618,0.0000440339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004552247,0.0001735908,0.01636431,0.000002811611,0.000006929889,0.000005563205,0.0006915662,0.000007159531,0.9760221,0.0001909112,0.0001120869,0.006377411],"study_design_scores_gemma":[0.0005502625,0.00008137934,0.7941108,0.00001042314,0.000001361922,0.00004933805,0.0001205929,0.000002049248,0.188058,0.0001879218,0.01671183,0.0001160868],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900703,0.00005866614,0.00002644438,0.0008401638,0.0005101333,0.0002016373,0.00001032066,0.00003236623,0.008249925],"genre_scores_gemma":[0.9955906,0.00001002683,0.0000978677,0.00002152312,0.00002761591,0.0000311531,0.000002905147,0.000007035104,0.004211264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7879642,"threshold_uncertainty_score":0.9999081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02526190505639451,"score_gpt":0.320758053624403,"score_spread":0.2954961485680085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}