{"id":"W2619565046","doi":"10.1126/science.aai9383","title":"Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women","year":2017,"lang":"en","type":"article","venue":"Science","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":416,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"Canadian Institutes of Health Research; Public Health Agency; Department of Science and Technology, Ministry of Science and Technology, India; University of Washington; National Research Foundation; Public Health Agency of Canada; National Institute of Allergy and Infectious Diseases; Manitoba Health Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; United States Agency for International Development","keywords":"Microbicide; Bacterial vaginosis; Gardnerella vaginalis; Lactobacillus; Microbicides for sexually transmitted diseases; Microbiology; Bacteria; Anaerobic bacteria; Tenofovir; Lactobacillus crispatus; Human immunodeficiency virus (HIV); Vagina; Medicine; Biology; Virology; Population; Surgery; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001667873,0.0001272497,0.0001360824,0.0001982692,0.0001955779,0.0003278902,0.00007428003,0.0002401487,0.002950192],"category_scores_gemma":[0.001057189,0.0001331346,0.0001247961,0.0001955404,0.0001835814,0.0001903803,0.0001418776,0.0002588619,0.0001417731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000218307,"about_ca_system_score_gemma":0.0001862544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001503289,"about_ca_topic_score_gemma":0.001593848,"domain_scores_codex":[0.9998919,0.00004170466,0.000004755444,0.00001108732,0.0000138381,0.00003670007],"domain_scores_gemma":[0.9998448,0.0000502051,0.00006107947,0.0000082072,0.000009546222,0.00002617882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01076064,0.001306542,0.6961522,0.0002677403,0.000220339,0.001337547,0.001986594,0.0003218239,0.1512554,0.0009556371,0.0009599483,0.1344756],"study_design_scores_gemma":[0.0001138334,0.003159472,0.9764776,0.00008416171,0.0001601697,0.001219054,0.001346237,0.0004592793,0.01264259,0.0004084444,0.003913906,0.0000154289],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981989,0.0008810174,0.00003725929,0.0001032339,0.000007680022,0.000006522564,0.00004179816,0.00000207495,0.0007215181],"genre_scores_gemma":[0.9992402,0.0002822899,0.00005870174,0.00003116829,0.000003678865,0.000003512434,0.00001631189,0.000001587871,0.0003625628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002950192,"threshold_uncertainty_score":0.009869397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02526190505639451,"score_gpt":0.320758053624403,"score_spread":0.2954961485680085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}