{"id":"W2619639643","doi":"10.1182/blood.v128.22.1716.1716","title":"Inhibition of c-Myc By Apto-253 As an Innovative Therapeutic Approach to Induce Cell Cycle Arrest and Apoptosis in Acute Myeloid Leukemia","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aptose Biosciences (Canada)","funders":"","keywords":"Myeloid leukemia; Cell cycle; Cancer research; Apoptosis; Cell cycle checkpoint; Biology; Myeloid; Leukemia; Annexin A5; Oncogene; Programmed cell death; Molecular biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009677578,0.0001342503,0.0001378616,0.00005618522,0.00003004456,0.00001111021,0.00009633903,0.0001543945,0.000002456392],"category_scores_gemma":[0.00001059408,0.0001080705,0.00002112178,0.0001891637,0.00006228076,0.000006951314,0.00005374146,0.00005783738,0.000002956813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001415833,"about_ca_system_score_gemma":0.00007672251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000354252,"about_ca_topic_score_gemma":0.0000227148,"domain_scores_codex":[0.9991724,0.00004457466,0.0001811273,0.0003126145,0.00009577383,0.0001935166],"domain_scores_gemma":[0.9995599,0.000006781283,0.00006906054,0.000229434,0.0000784044,0.00005635533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000775533,0.0002564493,0.001450393,0.00001592469,0.00003347942,4.89016e-7,0.0002573643,0.000002157236,0.9960979,0.00004915644,0.00007380149,0.001685334],"study_design_scores_gemma":[0.001240244,0.0004604888,0.003092408,0.00001889642,0.00002139812,0.000002403517,0.0001200952,0.000001387621,0.9942513,0.0001458018,0.0004803591,0.0001652601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972026,0.0002805987,0.0003516246,0.00004414944,0.00002318645,0.0001897758,0.00004836071,0.000005252663,0.001854444],"genre_scores_gemma":[0.9986014,0.000230619,0.0005722464,0.000274363,0.00004910579,0.00003187915,0.00006242967,0.00001809327,0.0001598463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00184664,"threshold_uncertainty_score":0.4406988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006770400588782471,"score_gpt":0.2249806623728683,"score_spread":0.2182102617840858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}