{"id":"W2619680547","doi":"10.1101/142265","title":"Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Hospital for Sick Children; Canadian Institutes of Health Research; John T. Reid Charitable Trusts; Universitetet i Bergen; Scheme for Promotion of Academic and Research Collaboration; University of Toronto; Academy of Finland","keywords":"Interactome; Regulator; AMPA receptor; Endocytic cycle; Cell biology; Excitatory postsynaptic potential; Neuroscience; Biology; Gene knockdown; HEK 293 cells; Small hairpin RNA; Chemistry; Glutamate receptor; Receptor; Inhibitory postsynaptic potential; Gene; Biochemistry; Endocytosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009649139,0.0003538998,0.0003194204,0.0003541356,0.0003408804,0.000362574,0.0002048726,0.0002561331,0.001480471],"category_scores_gemma":[0.0001062324,0.000126642,0.0002233572,0.0002584998,0.0001716591,0.0001869197,0.0002316758,0.0003759898,0.0005163985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005015279,"about_ca_system_score_gemma":0.0002247504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001092563,"about_ca_topic_score_gemma":0.00170183,"domain_scores_codex":[0.9998822,0.000006161125,0.000008487228,0.00005019798,0.00003270535,0.00002030072],"domain_scores_gemma":[0.999927,0.000008657215,0.00001875282,0.00001073364,0.00001467554,0.00002013084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007269901,0.000005586695,0.0007890162,0.0000262614,0.000007457332,0.0001465189,0.00001316485,0.00005915045,0.9982161,0.00009171227,0.0001136155,0.0004586412],"study_design_scores_gemma":[0.0000190467,0.00006548218,0.0758581,0.00001341675,0.00005133886,0.002240542,0.00009295221,0.00550481,0.9066764,0.000332298,0.009127906,0.00001774615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924605,0.001259214,0.003031227,0.0001746443,0.00002784463,0.000009380215,0.001877652,0.000102373,0.001057195],"genre_scores_gemma":[0.989813,0.0004876413,0.002965328,0.0001074231,0.00001637069,0.00002259463,0.003373957,0.0000558506,0.003157759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001480471,"threshold_uncertainty_score":0.00495261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01312184295894009,"score_gpt":0.2605286997962504,"score_spread":0.2474068568373103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}