{"id":"W2619745853","doi":"10.1182/blood.v128.22.1441.1441","title":"Pharmacokinetics (PK) and Pharmacodynamics (PD), Safety and Tolerability of a Single-Dose Oral Solution of Dabigatran Etexilate Given after Standard Anticoagulant Therapy in Children from Birth to Less Than One Year Old, with Venous Thromboembolism","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; University of Alberta; Children's Hospital of Eastern Ontario; Hospital for Sick Children; University of Ottawa","funders":"","keywords":"Medicine; Dabigatran; Tolerability; Pharmacodynamics; Pharmacokinetics; Dosing; Gestational age; Anesthesia; Pediatrics; Internal medicine; Adverse effect; Warfarin; Atrial fibrillation; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004988175,0.0004784792,0.0009209258,0.0001899527,0.0001770317,0.000385775,0.0002580426,0.0003194688,0.00107204],"category_scores_gemma":[0.001120588,0.0001819621,0.0005211103,0.0002509244,0.0003995495,0.0003655939,0.0001417405,0.0008087264,0.0001824113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004472984,"about_ca_system_score_gemma":0.0004864397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006602691,"about_ca_topic_score_gemma":0.0005397965,"domain_scores_codex":[0.9996327,0.0001243574,0.00003764399,0.00007077722,0.00008225028,0.00005230524],"domain_scores_gemma":[0.9993693,0.0001496003,0.0002584477,0.00005138908,0.00005337201,0.0001179646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4706879,0.03398696,0.0742036,0.001686175,0.001675505,0.000884295,0.0007699744,0.00431843,0.2419142,0.0002564902,0.00142812,0.1681884],"study_design_scores_gemma":[0.03223779,0.6634979,0.2227679,0.00007403307,0.001303556,0.002184827,0.0003064586,0.004602301,0.06872001,0.0001027114,0.004137438,0.00006512475],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983955,0.00088677,0.0002973316,0.00001927689,0.000008451903,0.0001264678,0.0001192771,0.00001048638,0.0001365043],"genre_scores_gemma":[0.998405,0.0004970706,0.0005497675,0.00003026122,0.00001734193,0.0001387319,0.0001637202,0.000004112013,0.0001939257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00107204,"threshold_uncertainty_score":0.003586352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03037683305658886,"score_gpt":0.2951833400880756,"score_spread":0.2648065070314867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}