{"id":"W2619745853","doi":"10.1182/blood.v128.22.1441.1441","title":"Pharmacokinetics (PK) and Pharmacodynamics (PD), Safety and Tolerability of a Single-Dose Oral Solution of Dabigatran Etexilate Given after Standard Anticoagulant Therapy in Children from Birth to Less Than One Year Old, with Venous Thromboembolism","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; University of Alberta; Children's Hospital of Eastern Ontario; Hospital for Sick Children; University of Ottawa","funders":"","keywords":"Medicine; Dabigatran; Tolerability; Pharmacodynamics; Pharmacokinetics; Dosing; Gestational age; Anesthesia; Pediatrics; Internal medicine; Adverse effect; Warfarin; Atrial fibrillation; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002609646,0.0001808891,0.0006372916,0.00005647698,0.00003604219,0.000009741491,0.00006463953,0.00005877619,0.00003125234],"category_scores_gemma":[0.00002952592,0.0001182152,0.00003695562,0.000132172,0.0002298984,0.0000978756,0.00007528425,0.000137756,4.881354e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002663636,"about_ca_system_score_gemma":0.00003434063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004628164,"about_ca_topic_score_gemma":0.0001296138,"domain_scores_codex":[0.9987481,0.0001007873,0.0003393375,0.0003049175,0.0002597382,0.0002470819],"domain_scores_gemma":[0.9993271,0.000140619,0.0001300757,0.0001667259,0.00008411391,0.0001513446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01109404,0.001889042,0.6282764,0.0001106571,0.0006802848,0.00001424212,0.001173155,0.000003619101,0.3272506,0.00000893834,0.000001809221,0.02949715],"study_design_scores_gemma":[0.01550182,0.001869665,0.9064216,0.0003040486,0.0005154146,0.00001739777,0.00005478867,0.00004945804,0.0748265,0.00006152447,0.0001994336,0.0001783171],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996044,0.001431259,0.0001267515,0.001092306,0.00003086193,0.000653398,0.0005659138,0.00001626967,0.0000392431],"genre_scores_gemma":[0.9941452,0.004802214,0.0008242917,0.0001332122,0.00005418794,0.000007953729,0.00000761809,0.00002149258,0.000003810505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2781452,"threshold_uncertainty_score":0.4820674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03037683305658886,"score_gpt":0.2951833400880756,"score_spread":0.2648065070314867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}