{"id":"W2619755571","doi":"10.1038/ncomms15277","title":"Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alzheimer's Association; National Institute on Aging; National Institute of Neurological Disorders and Stroke; Tau Consortium; University of California, San Francisco; McGill University; University of California, Los Angeles; National Institutes of Health; Yale University; University of Cincinnati; Muscular Dystrophy Association; Aarhus Universitet","keywords":"Frontotemporal lobar degeneration; Haploinsufficiency; Neuronal ceroid lipofuscinosis; Batten disease; Mutation; Cell biology; Biology; Neurodegeneration; Frontotemporal dementia; Neuroscience; Cancer research; Gene; Genetics; Phenotype; Disease; Medicine; Pathology; Dementia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001631002,0.0006638014,0.0002674267,0.0007745531,0.0001821091,0.0002642897,0.0001792182,0.0005056426,0.0007890832],"category_scores_gemma":[0.0002195603,0.0002253104,0.000173619,0.0001810882,0.0005295958,0.0001817088,0.0003231927,0.0002709507,0.0003054648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003566414,"about_ca_system_score_gemma":0.0001673249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008637222,"about_ca_topic_score_gemma":0.00126879,"domain_scores_codex":[0.9998972,0.00002064022,0.00001417639,0.00001982514,0.00003141821,0.00001661813],"domain_scores_gemma":[0.9999084,0.0000190317,0.0000309961,0.00000672715,0.000007072025,0.00002770323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000603385,0.00005010751,0.005525352,0.00006870066,0.00004552548,0.01119842,0.0001116961,0.0002901302,0.9777306,0.0002068517,0.0001503169,0.004018794],"study_design_scores_gemma":[0.0002517702,0.0008467087,0.2529419,0.00004935025,0.0002716872,0.07511661,0.0002668956,0.003432158,0.6609491,0.001201839,0.004624094,0.00004797347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984379,0.0005102938,0.0002937027,0.00004072445,0.000005988827,0.000004234671,0.00005990355,0.00002438433,0.0006228859],"genre_scores_gemma":[0.9983898,0.0003452846,0.0005433094,0.00004023627,0.000005796811,0.000006973989,0.0001074084,0.0000119275,0.0005492592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008637222,"threshold_uncertainty_score":0.002639711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05446389338922312,"score_gpt":0.3788385910147948,"score_spread":0.3243746976255716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}