{"id":"W2619830557","doi":"10.1002/cam4.1083","title":"Optimization of liposomal topotecan for use in treating neuroblastoma","year":2017,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Centre for Drug Research and Development; BC Children's Hospital; BC Cancer Agency; University of British Columbia Hospital","funders":"Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"Topotecan; Liposome; Pharmacokinetics; Pharmacology; Neuroblastoma; Chemistry; Drug; Medicine; Cell culture; Chemotherapy; Internal medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001874005,0.000350236,0.0003185354,0.0002129353,0.0001319762,0.0004854678,0.0002326531,0.0002818198,0.0006127963],"category_scores_gemma":[0.0002002858,0.0001244188,0.0001732366,0.0001982787,0.0001692842,0.0002327638,0.0002207941,0.000310501,0.0003069423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005612631,"about_ca_system_score_gemma":0.0004705166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001013469,"about_ca_topic_score_gemma":0.001655083,"domain_scores_codex":[0.9998779,0.00002406288,0.00001415703,0.00001882344,0.00004581194,0.00001917103],"domain_scores_gemma":[0.9999572,0.000007269644,0.000009048563,0.000002359955,0.00001474262,0.000009365651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001699446,0.00004525539,0.0001590619,0.00007124312,0.00001421346,0.0000771788,0.00001402042,0.001121226,0.99274,0.0001171578,0.00005951768,0.005411255],"study_design_scores_gemma":[0.00007704891,0.000523103,0.0009380446,0.000009032346,0.00005147686,0.000193358,0.00002134637,0.002796305,0.9913914,0.00003867514,0.003946981,0.00001318296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802142,0.003855624,0.01332412,0.0001781943,0.00004581596,0.0002636126,0.0003227116,0.0001014494,0.00169439],"genre_scores_gemma":[0.9819932,0.002128527,0.01378453,0.00007514124,0.00001356081,0.0001403673,0.0003875185,0.00003971513,0.001437409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001013469,"threshold_uncertainty_score":0.004072309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06992656900929009,"score_gpt":0.3815591657567621,"score_spread":0.311632596747472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}