{"id":"W2619984498","doi":"10.1126/sciadv.1601898","title":"CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair","year":2017,"lang":"en","type":"article","venue":"Science Advances","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fondation du cancer du sein du Québec; McGill University","keywords":"Homologous recombination; Homologous chromosome; Recombination; DNA repair; DNA; CTCF; Genetics; Cell biology; Non-homologous end joining; Biology; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009800249,0.0001806546,0.0001591598,0.00005770966,0.0009590384,0.0001283305,0.0007467641,0.00009601182,0.00002027441],"category_scores_gemma":[0.0004402419,0.0001670842,0.0001243864,0.0001093598,0.0008309309,0.000121454,0.0002194747,0.00008424558,0.00002254395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003931579,"about_ca_system_score_gemma":0.0001351049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004707918,"about_ca_topic_score_gemma":0.0001503514,"domain_scores_codex":[0.998126,0.00002969506,0.0002411917,0.0008200709,0.000333038,0.0004499912],"domain_scores_gemma":[0.9985178,0.00001583235,0.0002034344,0.0009640328,0.0001725959,0.0001262874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004884465,0.00003950373,0.0006081031,0.00001846166,0.000009313202,0.000004186033,0.00006548088,0.00001425328,0.9919184,0.0001078227,0.0006246028,0.006541055],"study_design_scores_gemma":[0.0004969662,0.0003411504,0.0005683823,0.00002129825,0.000008079126,0.00002012035,0.0001808761,0.00004951888,0.9685463,0.0009628082,0.02856916,0.0002353165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922783,0.001357112,0.0006779026,0.000216886,0.0007177564,0.0002520753,0.00002170851,0.0001544695,0.004323767],"genre_scores_gemma":[0.9915488,0.0001675241,0.004054605,0.00009753491,0.00006529127,0.00003725806,0.00002638696,0.00001306491,0.003989586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02794456,"threshold_uncertainty_score":0.7376245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009934007373278328,"score_gpt":0.2798261456654086,"score_spread":0.2698921382921303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}