{"id":"W2619988375","doi":"10.1093/molehr/gax029","title":"Intergenerational impact of paternal lifetime exposures to both folic acid deficiency and supplementation on reproductive outcomes and imprinted gene methylation","year":2017,"lang":"en","type":"article","venue":"Molecular Human Reproduction","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; McGill University; William Osler Health System; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Biology; Methylation; Folic acid; Folic acid supplementation; Genomic imprinting; DNA methylation; Endocrinology; Genetics; Imprinting (psychology); Gene; Internal medicine; Pregnancy; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002413448,0.0001771013,0.000238365,0.0001654476,0.0001331139,0.00019506,0.000144417,0.0002241249,0.001263293],"category_scores_gemma":[0.0002168674,0.0001107524,0.0001501147,0.00009875387,0.0001656375,0.0001349255,0.0002136599,0.0002675152,0.00008993316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002028825,"about_ca_system_score_gemma":0.0002302124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001290665,"about_ca_topic_score_gemma":0.003096425,"domain_scores_codex":[0.9998982,0.00002120861,0.000005844661,0.00003584283,0.00002106251,0.00001784508],"domain_scores_gemma":[0.9997675,0.00003645726,0.00008910662,0.0000247987,0.00002041357,0.00006173961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006765184,0.00048148,0.2713161,0.0002050656,0.0003795498,0.0005476709,0.0003151747,0.0002106789,0.6919214,0.0002993704,0.0003851362,0.02717309],"study_design_scores_gemma":[0.00004980408,0.004355436,0.9347026,0.00003491705,0.0003023913,0.0008652143,0.0002773531,0.0003590065,0.05709869,0.0002036992,0.001734453,0.00001647577],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981982,0.0007582352,0.0002630446,0.00007186213,0.000008768996,0.000007366918,0.0003495098,0.000005935216,0.0003369733],"genre_scores_gemma":[0.9962893,0.0009625835,0.0004922325,0.00006409195,0.000006600337,0.00002200022,0.0004562105,0.000004715299,0.001702333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001290665,"threshold_uncertainty_score":0.004226148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01666211461636326,"score_gpt":0.3195948542729148,"score_spread":0.3029327396565516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}