{"id":"W2620071155","doi":"10.18632/oncotarget.18070","title":"Lysine methylation of FEN1 by SET7 is essential for its cellular response to replicative stress","year":2017,"lang":"en","type":"article","venue":"Oncotarget","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Ottawa; Université Laval; McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Health Canada","keywords":"Methylation; DNA repair; Biology; Okazaki fragments; Methyltransferase; DNA replication; Histone; DNA damage; Histone methyltransferase; DNA methylation; Cell biology; Histone H4; Molecular biology; Biochemistry; DNA; Eukaryotic DNA replication; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004505984,0.0001215563,0.0001627503,0.00003469917,0.0001621594,0.00003525326,0.0002450492,0.0001334312,0.00002284877],"category_scores_gemma":[0.0005189539,0.000123653,0.00009236721,0.00003621635,0.00003967734,0.000006844303,0.00009842894,0.00003638168,0.000006006653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001242339,"about_ca_system_score_gemma":0.00004944425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001715059,"about_ca_topic_score_gemma":0.000008470608,"domain_scores_codex":[0.9990551,0.00006961969,0.0002270561,0.0003573423,0.0001298375,0.0001609782],"domain_scores_gemma":[0.9986804,0.00003223235,0.0002661745,0.0006829815,0.0002576227,0.0000806033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006194895,0.00005581825,0.001234063,0.00001751167,0.0000386454,2.381694e-7,0.0001089618,0.00004586203,0.9943888,0.00002673768,0.002739502,0.0007243243],"study_design_scores_gemma":[0.0004618632,0.0004328502,0.002476556,0.000009308075,0.00002256514,7.7267e-8,0.00001747292,0.000162791,0.9224603,0.0001381555,0.07368571,0.0001323935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.967399,0.0008970189,0.02925544,0.001084828,0.0001183602,0.0003758602,0.0005686475,0.000004708138,0.0002961068],"genre_scores_gemma":[0.9938117,0.00008071789,0.003147674,0.00006610572,0.0001607571,0.00004166711,0.0004019527,0.00002235223,0.00226705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07192859,"threshold_uncertainty_score":0.5042424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01419618930602568,"score_gpt":0.3212848883183397,"score_spread":0.307088699012314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}