{"id":"W2620071155","doi":"10.18632/oncotarget.18070","title":"Lysine methylation of FEN1 by SET7 is essential for its cellular response to replicative stress","year":2017,"lang":"en","type":"article","venue":"Oncotarget","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Ottawa; Université Laval; McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Health Canada","keywords":"Methylation; DNA repair; Biology; Okazaki fragments; Methyltransferase; DNA replication; Histone; DNA damage; Histone methyltransferase; DNA methylation; Cell biology; Histone H4; Molecular biology; Biochemistry; DNA; Eukaryotic DNA replication; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002685625,0.0003198003,0.0004796174,0.000183163,0.0006946536,0.0006691011,0.0005102073,0.0004971649,0.00444577],"category_scores_gemma":[0.0004224455,0.0002320676,0.0004112034,0.0001525615,0.0003159106,0.0003920164,0.0007615195,0.0006340846,0.002256575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007380188,"about_ca_system_score_gemma":0.0005130263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002135662,"about_ca_topic_score_gemma":0.003384856,"domain_scores_codex":[0.9997634,0.00002331427,0.0000167601,0.00006101646,0.00007871351,0.0000567872],"domain_scores_gemma":[0.9996674,0.00003801444,0.00007293237,0.00003937939,0.00008294253,0.00009932147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004390173,0.00002899258,0.002602105,0.0001053445,0.00001685113,0.0001504726,0.0000739607,0.00016731,0.9868292,0.0004091951,0.001038703,0.008138829],"study_design_scores_gemma":[0.00003062121,0.0001898948,0.05725779,0.00005609598,0.0000301889,0.0006224725,0.0003071042,0.002421557,0.9219323,0.0004622538,0.01665547,0.0000341456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972629,0.01111666,0.005258327,0.0009035519,0.0002977876,0.00002893686,0.001493436,0.0004129732,0.007859263],"genre_scores_gemma":[0.9857905,0.001641872,0.001556281,0.0001723419,0.00002825147,0.00002592093,0.001826756,0.0001282377,0.008829912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00444577,"threshold_uncertainty_score":0.01487255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01419618930602568,"score_gpt":0.3212848883183397,"score_spread":0.307088699012314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}