{"id":"W2620092731","doi":"10.1371/journal.pone.0178489","title":"Identification of function-regulating antibodies targeting the receptor protein tyrosine phosphatase sigma ectodomain","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Occupational Cancer Research Centre","funders":"Canadian Institutes of Health Research; Azrieli Foundation; Israel Science Foundation; International Development Research Centre","keywords":"Ectodomain; Protein tyrosine phosphatase; Heparan sulfate; Luciferase; Chondroitin sulfate; Neurite; Cell biology; Phosphatase; Pleiotrophin; Biochemistry; Tyrosine; Chemistry; Receptor; Biology; Glycosaminoglycan; Phosphorylation; In vitro; Transfection; Growth factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000521231,0.0001547571,0.0001806595,0.00002160023,0.0005715892,0.00009873378,0.0004387646,0.00008379047,0.00004098625],"category_scores_gemma":[0.00174885,0.0001271222,0.00006517663,0.00004789603,0.0002390852,0.00002164197,0.0002412185,0.00008746309,0.0000158954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001099627,"about_ca_system_score_gemma":0.00003779868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005978517,"about_ca_topic_score_gemma":0.000009320406,"domain_scores_codex":[0.9987724,0.00006667327,0.0003667485,0.0003261097,0.0002562693,0.0002117595],"domain_scores_gemma":[0.9981821,0.00002079625,0.0005983458,0.0009565317,0.0002006243,0.00004165116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001334566,0.0002267739,0.002402751,0.0001034118,0.0001342056,3.841978e-7,0.0000176427,0.000009203872,0.9943298,0.001091351,0.0007332636,0.0008177715],"study_design_scores_gemma":[0.0003498815,0.00012733,0.003508166,0.0001361456,0.00006548058,4.416949e-7,0.00003010395,0.0001103177,0.9949666,0.0002333944,0.0003225039,0.0001496223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874084,0.00990573,0.0009500891,0.0005613643,0.00007576697,0.0007762946,0.0002281088,0.00002317122,0.00007107303],"genre_scores_gemma":[0.9960305,0.00009401672,0.002559751,0.00003444781,0.0002873018,0.0001124043,0.0004075199,0.00002817259,0.0004458777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009811713,"threshold_uncertainty_score":0.5183893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02173152122423766,"score_gpt":0.2426164099396085,"score_spread":0.2208848887153708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}