{"id":"W2620146959","doi":"10.1002/jin2.25","title":"The curious case of how mimicking physiological complexity in in vitro models of the human respiratory system influences the inflammatory responses. A preliminary study focused on gold nanoparticles","year":2017,"lang":"en","type":"article","venue":"Journal of Interdisciplinary Nanomedicine","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Seventh Framework Programme","keywords":"In vitro; Secretion; A549 cell; Colloidal gold; Monocyte; Confocal microscopy; Nanotoxicology; Cell biology; Cell culture; Chemistry; Biophysics; Nanotechnology; Materials science; Nanoparticle; Biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003359616,0.0002273576,0.000762014,0.0003192853,0.0005802941,0.00003159399,0.0007696401,0.0001033013,0.000002271222],"category_scores_gemma":[0.0004309189,0.00009566995,0.0002391194,0.0002156917,0.001369384,0.0002118841,0.0005703307,0.0007821684,4.576304e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002202877,"about_ca_system_score_gemma":0.0002329125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003098517,"about_ca_topic_score_gemma":0.0001168248,"domain_scores_codex":[0.9965317,0.0009577741,0.001436595,0.0002086772,0.0006065122,0.0002588024],"domain_scores_gemma":[0.9962549,0.0005620643,0.00187875,0.0008915034,0.0003271724,0.00008562375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03704014,0.003873694,0.1114662,0.000903271,0.0005548254,0.01349357,0.04462581,0.002229212,0.7790545,0.0006103154,0.0009408749,0.005207606],"study_design_scores_gemma":[0.01075776,0.009439566,0.8768381,0.005523326,0.0002533073,0.00161265,0.06308641,0.002771746,0.02896194,0.0004749238,0.0000343775,0.0002458932],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951138,0.0007159586,0.000001276455,0.002831783,0.0003196805,0.0008292065,0.000005373212,0.000006924833,0.0001760149],"genre_scores_gemma":[0.9995733,0.000009103028,0.000009643913,0.000130445,0.0002003116,0.00001686857,2.444206e-7,0.00001567728,0.00004440269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7653719,"threshold_uncertainty_score":0.5045553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09573185363591886,"score_gpt":0.3607733220230735,"score_spread":0.2650414683871546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}