{"id":"W2620353794","doi":"10.15173/m.v1i22.818","title":"Compound 186 is a Negative Allosteric Modulator of Dopamine D2 Receptors: Implications for Improving Schizophrenia Therapy","year":2013,"lang":"en","type":"article","venue":"The Meducator","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Allosteric modulator; Schizophrenia (object-oriented programming); Allosteric regulation; Neuroscience; Dopamine receptor D3; Dopamine; Dopamine receptor D2; Receptor; Dopamine receptor; Pharmacology; Psychology; Medicine; Psychiatry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001374806,0.0003675629,0.0002914846,0.0002629998,0.0001254077,0.0002337016,0.0002475209,0.000274457,0.003929341],"category_scores_gemma":[0.00009542055,0.0001125946,0.0001835697,0.0001714675,0.0002322418,0.0002420043,0.0001283365,0.000456489,0.0005640037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002974725,"about_ca_system_score_gemma":0.0002876006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006493655,"about_ca_topic_score_gemma":0.002303131,"domain_scores_codex":[0.9999715,0.000007407873,0.000002730235,0.000004133504,0.000005887985,0.000008338146],"domain_scores_gemma":[0.9999719,0.000004166211,0.00001056557,0.000001895726,0.000003280735,0.000008122672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002948207,0.0009902554,0.002267298,0.001292974,0.00005634599,0.0008991,0.0001079843,0.001923776,0.7374952,0.006621438,0.004552306,0.2408451],"study_design_scores_gemma":[0.006664496,0.04394835,0.05495934,0.0005986965,0.0004658795,0.00630923,0.0002850345,0.005774592,0.5962189,0.004800595,0.2797589,0.0002159826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8048144,0.1440183,0.006619521,0.006983474,0.0003569272,0.0004285765,0.001170057,0.0004511414,0.03515753],"genre_scores_gemma":[0.9062631,0.07255874,0.007107633,0.001300271,0.0002024918,0.0001044131,0.0004999547,0.00002540561,0.01193809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003929341,"threshold_uncertainty_score":0.01314497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02397032080711958,"score_gpt":0.2677834851154008,"score_spread":0.2438131643082812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}