{"id":"W2620447119","doi":"10.3389/fcimb.2017.00226","title":"Immunogenicity and Protective Efficacy of a Fusion Protein Tuberculosis Vaccine Combining Five Esx Family Proteins","year":2017,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Science and Technology Commission of Shanghai Municipality; Natural Science Foundation of Shanghai","keywords":"Immunogenicity; Antigen; Tuberculosis vaccines; Mycobacterium tuberculosis; Fusion protein; Adjuvant; Vaccination; Immunization; Virology; Mycobacterium bovis; Tuberculosis; Booster dose; Recombinant DNA; Biology; Microbiology; Immunology; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000380245,0.0003115952,0.0002768243,0.0001837846,0.00009215773,0.0002103453,0.0001590306,0.0003631212,0.0006465107],"category_scores_gemma":[0.0002684511,0.000103647,0.0002248777,0.0001255761,0.0002279031,0.0003031534,0.0001678799,0.0007274987,0.0001546816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001675316,"about_ca_system_score_gemma":0.0001308486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002199221,"about_ca_topic_score_gemma":0.0001193773,"domain_scores_codex":[0.9997889,0.00005827068,0.00001769268,0.00003084232,0.00004995595,0.0000543697],"domain_scores_gemma":[0.9998263,0.00004842591,0.00003288886,0.0000201492,0.00002819434,0.00004400756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006633406,0.0002840842,0.0008059915,0.00003436553,0.0000140711,0.0000390809,0.00002304487,0.0002995136,0.9955724,0.00005542653,0.00002914598,0.002179441],"study_design_scores_gemma":[0.0001206392,0.01246918,0.01239236,0.00001585199,0.0000993841,0.0004171937,0.00005402921,0.00254892,0.9703497,0.0001033838,0.001422605,0.000006893638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988921,0.0004154262,0.0003977962,0.000028314,0.00001214502,0.000007377694,0.00003949807,0.00000484848,0.0002025025],"genre_scores_gemma":[0.9988354,0.00023131,0.0003396297,0.00002070917,0.00001044134,0.000008397902,0.0001777076,0.00000289732,0.0003735316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006465107,"threshold_uncertainty_score":0.002162755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01357942915166725,"score_gpt":0.2712206576249068,"score_spread":0.2576412284732396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}