{"id":"W2620480106","doi":"","title":"Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells","year":2015,"lang":"en","type":"article","venue":"DSpace@MIT (Massachusetts Institute of Technology)","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biology; Provirus; Chromatin; Gene silencing; SUMO protein; Embryonic stem cell; Endogenous retrovirus; Genetics; Psychological repression; Histone; Epigenetics; Retrotransposon; Polycomb-group proteins; Cell biology; Genome; Transcription factor; Repressor; Gene; Transposable element; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006248308,0.0007405938,0.0005014072,0.001104475,0.0004363889,0.0008853403,0.0005847151,0.0003429951,0.00218849],"category_scores_gemma":[0.0005762497,0.0006141622,0.0008233716,0.0004605771,0.0005749558,0.0003968083,0.0005188405,0.001266248,0.001186602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000961086,"about_ca_system_score_gemma":0.0009968295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001373667,"about_ca_topic_score_gemma":0.003670986,"domain_scores_codex":[0.9995306,0.00005534247,0.0000792522,0.0001081402,0.0001470306,0.00007970106],"domain_scores_gemma":[0.9993501,0.0002743822,0.0001198893,0.0001148711,0.00006668823,0.0000740244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003582548,0.00001448906,0.0001662923,0.00002280144,0.000005696796,0.00003442071,0.00001277106,0.0000489822,0.9971942,0.0002932034,0.00004431796,0.002127097],"study_design_scores_gemma":[0.000009608561,0.000057164,0.0008613121,0.000004782847,0.00002637268,0.00009905476,0.00002054663,0.0003681131,0.9954314,0.00008524222,0.003032361,0.00000404112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8718406,0.006902613,0.1066374,0.0005142206,0.0001474552,0.0007776871,0.003124346,0.001217295,0.008838289],"genre_scores_gemma":[0.9442691,0.002201647,0.04141487,0.000211839,0.00003332763,0.0002188198,0.003983648,0.0006452802,0.007021458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00218849,"threshold_uncertainty_score":0.007321298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02751374982287667,"score_gpt":0.2863770765063734,"score_spread":0.2588633266834967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}