{"id":"W2620559408","doi":"10.1126/science.aaf8310","title":"mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate","year":2017,"lang":"en","type":"article","venue":"Science","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Forschungsgemeinschaft; Banting Research Foundation; Alexander von Humboldt-Stiftung","keywords":"Endosome; Phosphatidylinositol 4,5-bisphosphate; mTORC1; Psychological repression; Phosphatidylinositol; Cell biology; Chemistry; Biology; Biochemistry; PI3K/AKT/mTOR pathway; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000111741,0.0003051993,0.0001551313,0.000204374,0.0002223998,0.00043927,0.0001955893,0.0002066661,0.002132085],"category_scores_gemma":[0.000140388,0.0001212065,0.0001854343,0.0001849563,0.0002933365,0.0002611323,0.0002532112,0.0005624247,0.0006066346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006015776,"about_ca_system_score_gemma":0.0004910115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008633959,"about_ca_topic_score_gemma":0.001466304,"domain_scores_codex":[0.9999084,0.00001445855,0.000007907161,0.00001922908,0.00002137933,0.00002864446],"domain_scores_gemma":[0.9999508,0.00001000098,0.00001084566,0.000006314694,0.000007293958,0.00001476233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000437193,0.00003186482,0.00009209091,0.00004112602,0.000005176373,0.0000516395,0.000008360837,0.00007579673,0.9959474,0.000779805,0.00018671,0.002342795],"study_design_scores_gemma":[0.00002074726,0.00007021921,0.001483249,0.000005768376,0.00001055638,0.0001219136,0.00001746741,0.0006028387,0.9948729,0.0001559745,0.002634818,0.000003534457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761462,0.007613003,0.003826863,0.0007577611,0.0001497979,0.00002653535,0.001044079,0.0001884264,0.01024743],"genre_scores_gemma":[0.9924121,0.001614576,0.00109812,0.0000776661,0.00001832683,0.00002482206,0.0006452038,0.00003051687,0.004078498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002132085,"threshold_uncertainty_score":0.00713253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009758766424552678,"score_gpt":0.3006198071990617,"score_spread":0.290861040774509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}