{"id":"W2620650162","doi":"10.1097/brs.0000000000002258","title":"ADAMTS5 Deficiency Protects Mice From Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration","year":2017,"lang":"en","type":"article","venue":"Spine","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Shriners Hospitals for Children - Canada","funders":"National Heart, Lung, and Blood Institute; National Institute on Aging","keywords":"Aggrecan; ADAMTS; Intervertebral disc; Medicine; Aggrecanase; Western blot; Proteoglycan; Pathology; Immunology; Metalloproteinase; Molecular biology; Andrology; Matrix metalloproteinase; Thrombospondin; Osteoarthritis; Internal medicine; Anatomy; Chemistry; Biochemistry; Biology; Cartilage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003534612,0.001059956,0.0006583259,0.001311058,0.0004307981,0.0005676348,0.0006169595,0.001118078,0.004539289],"category_scores_gemma":[0.0001898602,0.0005085577,0.0008236678,0.0003538438,0.0006908505,0.0004513038,0.0004277808,0.001299816,0.001205603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005090514,"about_ca_system_score_gemma":0.0003777508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008651126,"about_ca_topic_score_gemma":0.001318606,"domain_scores_codex":[0.9995381,0.00004774004,0.00007750349,0.0001426764,0.00009629381,0.00009780947],"domain_scores_gemma":[0.9994681,0.00003501573,0.0002114587,0.00004722048,0.00003546354,0.0002026286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008728042,0.0002883735,0.000730303,0.00008363424,0.00002521996,0.0003032848,0.00004558178,0.00007272571,0.9957364,0.0001434867,0.00008357238,0.00161464],"study_design_scores_gemma":[0.000475907,0.00485309,0.02504199,0.0001148873,0.0002431161,0.002645778,0.0002174325,0.001488915,0.9592995,0.000209372,0.005375312,0.00003465074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913834,0.001703995,0.003357829,0.000232072,0.00008248301,0.0001555433,0.001566712,0.0002953802,0.001222521],"genre_scores_gemma":[0.9786509,0.002185296,0.004646536,0.0002464475,0.0000560953,0.0003468067,0.002339016,0.0001468557,0.01138208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004539289,"threshold_uncertainty_score":0.01518542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03958544227953818,"score_gpt":0.3183131420227314,"score_spread":0.2787276997431932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}