{"id":"W2620703224","doi":"10.1016/j.neo.2017.02.004","title":"A Novel Antagonist of the Immune Checkpoint Protein Adenosine A2a Receptor Restores Tumor-Infiltrating Lymphocyte Activity in the Context of the Tumor Microenvironment","year":2017,"lang":"en","type":"article","venue":"Neoplasia","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Cancer Institute; Moffitt Cancer Center","keywords":"Tumor microenvironment; Cancer research; Immune system; Adenosine A2A receptor; Immune checkpoint; Lung cancer; CD8; Immunotherapy; Context (archaeology); Tumor-infiltrating lymphocytes; T cell; Biology; Immunology; Medicine; Adenosine receptor; Receptor; Internal medicine; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003465464,0.000173183,0.000209608,0.00001353881,0.0002993787,0.00003215418,0.0008639222,0.00006812353,0.00001244076],"category_scores_gemma":[0.0002142996,0.00009527439,0.0001675344,0.00005441138,0.0003793873,0.000007892203,0.0003182747,0.0001726382,0.000001294646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003431902,"about_ca_system_score_gemma":0.0001435529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009417645,"about_ca_topic_score_gemma":0.0001307248,"domain_scores_codex":[0.9988841,0.000120555,0.0003327703,0.0002413498,0.0002159278,0.000205298],"domain_scores_gemma":[0.9982828,0.00002570759,0.0006189962,0.001019543,0.00003090432,0.00002200433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001753044,0.0001251843,0.007366784,0.00003644208,0.00002464272,0.000001583501,0.0002452828,0.00002196507,0.9914388,0.00004766024,0.0002484478,0.0002679053],"study_design_scores_gemma":[0.0008436244,0.0001033493,0.0891513,0.000134963,0.00001549473,0.00003707263,0.0003157073,0.00002403875,0.9061344,0.000005909589,0.003135019,0.00009913347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968683,0.001064855,0.00002532189,0.00104216,0.0001152949,0.0005138393,0.00004201997,0.000002247817,0.0003259567],"genre_scores_gemma":[0.9993203,0.00002649943,0.0001542859,0.0001211976,0.0001222545,0.00004185932,0.000005175459,0.00001683367,0.0001915906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08530441,"threshold_uncertainty_score":0.3885177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0112082486478818,"score_gpt":0.2313379877309708,"score_spread":0.220129739083089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}