{"id":"W2620718322","doi":"10.1126/science.aan0003","title":"A modular and enantioselective synthesis of the pleuromutilin antibiotics","year":2017,"lang":"en","type":"article","venue":"Science","topic":"Veterinary medicine and infectious diseases","field":"Veterinary","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Semisynthesis; Chemistry; Stereochemistry; Combinatorial chemistry; Bifunctional; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002433113,0.0007427244,0.0003247884,0.0003367608,0.0002614896,0.0003418426,0.0005517348,0.0005437603,0.00254854],"category_scores_gemma":[0.0002265683,0.0003001504,0.000361715,0.0003210703,0.0002819905,0.0005833063,0.0007217684,0.001074836,0.001665132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003448904,"about_ca_system_score_gemma":0.0004538954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003376017,"about_ca_topic_score_gemma":0.0007273483,"domain_scores_codex":[0.9997942,0.0000246765,0.00002037452,0.00004072233,0.00005263959,0.00006735975],"domain_scores_gemma":[0.9999322,0.00000706781,0.00001681539,0.00001304433,0.000009686808,0.0000212531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001277017,0.0003436324,0.0002742407,0.0004706487,0.00005254385,0.001557444,0.000220134,0.003413501,0.9175705,0.01277854,0.002830831,0.06036035],"study_design_scores_gemma":[0.0001028626,0.001178907,0.001016971,0.00005291136,0.00004439483,0.002127399,0.00005739521,0.003767545,0.9334466,0.001793566,0.0563308,0.00008060053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6986547,0.01029029,0.1796961,0.002774404,0.001354205,0.001040951,0.001746065,0.001835301,0.102608],"genre_scores_gemma":[0.9155409,0.006712503,0.06274987,0.0004682138,0.0001354456,0.0002298511,0.000753187,0.000149271,0.01326073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00254854,"threshold_uncertainty_score":0.008525729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04996504886324592,"score_gpt":0.3448480991126744,"score_spread":0.2948830502494285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}