{"id":"W2620753850","doi":"10.1016/j.jmb.2017.05.025","title":"Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10","year":2017,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Janssen Biotech; Canadian Institutes of Health Research; Innovative Medicines Initiative; Ministero dello Sviluppo Economico; Mitacs; U.S. Department of Energy; National Natural Science Foundation of China; Merck; Ontario Ministry of Economic Development and Innovation; Canadian Council for Indigenous Business; AbbVie; Novartis Pharma; Canada Foundation for Innovation; Argonne National Laboratory; Ontario Genomics Institute; Canadian Cancer Society Research Institute; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; European Federation of Pharmaceutical Industries and Associations; Takeda Pharmaceuticals U.S.A.; Pfizer; Boehringer Ingelheim; Wellcome Trust","keywords":"Ubiquitin; Ubiquitin ligase; Deubiquitinating enzyme; Mdm2; Biology; Proteasome; Cell biology; Drug discovery; Cancer research; Apoptosis; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001184168,0.0008608067,0.0005955617,0.0004594594,0.0003153699,0.0007409352,0.0007115117,0.0007195052,0.0009958778],"category_scores_gemma":[0.0007441601,0.0003653031,0.0005986017,0.0003153001,0.0004210532,0.0003572259,0.0003136419,0.001038946,0.0004876277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009274866,"about_ca_system_score_gemma":0.0005635571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008089723,"about_ca_topic_score_gemma":0.001474714,"domain_scores_codex":[0.9993687,0.0001235108,0.00007658874,0.0001053283,0.0002344438,0.00009144835],"domain_scores_gemma":[0.9995772,0.00007400084,0.00009927029,0.00008683274,0.0001077365,0.00005499811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002358501,0.0001632365,0.0002026322,0.000036954,0.00003696208,0.00006296984,0.00001587291,0.0005453386,0.9945436,0.0003441703,0.0001493388,0.003663047],"study_design_scores_gemma":[0.00005506694,0.0003945278,0.0002419987,0.000004031687,0.00004492076,0.0001786486,0.000009169406,0.001289573,0.9949603,0.00003829633,0.002778688,0.000004777475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9608325,0.004103576,0.02954626,0.0003148066,0.0001812032,0.0004963256,0.001445802,0.0002612209,0.002818253],"genre_scores_gemma":[0.9699643,0.001705528,0.02166249,0.0001048713,0.0000304337,0.0002090185,0.003181549,0.00009722182,0.003044707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001184168,"threshold_uncertainty_score":0.006729484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02453898379795043,"score_gpt":0.2909159984851162,"score_spread":0.2663770146871658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}