{"id":"W2620975370","doi":"10.1038/onc.2017.164","title":"Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3","year":2017,"lang":"en","type":"article","venue":"Oncogene","topic":"Magnolia and Illicium research","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute","keywords":"Homeobox protein NANOG; SOX2; Biology; Cancer research; Carcinogenesis; Cancer stem cell; AMPK; Cancer cell; Cancer; STAT3; Nanog Homeobox Protein; Kinase; Stem cell; Cell biology; Protein kinase A; Signal transduction; Embryonic stem cell; Biochemistry; Genetics; Induced pluripotent stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002134326,0.000164461,0.0004516337,0.0001461757,0.00007737711,0.00001540967,0.0001628381,0.0001013073,0.001008232],"category_scores_gemma":[0.00003421973,0.0001439738,0.00008194758,0.0001558108,0.0001902969,0.0002097521,0.00007986085,0.0001907118,0.000008548888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002250289,"about_ca_system_score_gemma":0.0003658464,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01521833,"about_ca_topic_score_gemma":0.0006407622,"domain_scores_codex":[0.9984884,0.00005277716,0.0004100945,0.0002871508,0.0004478259,0.0003137111],"domain_scores_gemma":[0.998627,0.00004267841,0.0003771577,0.0004834128,0.0003458074,0.0001239382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007288487,0.0003088219,0.05032428,0.0004004768,0.0000694106,0.000008310694,0.0002074114,0.00001697775,0.9282371,0.000009971556,0.002137191,0.01755122],"study_design_scores_gemma":[0.002581229,0.000187932,0.0819264,0.0005218044,0.00005997082,0.000006468403,0.00008252059,0.0003484181,0.9126375,0.00003343773,0.001482345,0.0001319554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957765,0.0006762684,0.00002359933,0.001685013,0.0001304068,0.0005196044,0.0005151536,0.00001270074,0.0006607616],"genre_scores_gemma":[0.9978003,0.0006697333,0.00005552469,0.0001177674,0.0001441645,0.0001228474,0.00006225873,0.00003169482,0.0009957401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03160212,"threshold_uncertainty_score":0.999905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02450354132719727,"score_gpt":0.3328394792164737,"score_spread":0.3083359378892764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}