{"id":"W2621014337","doi":"10.1016/j.virol.2017.05.018","title":"The interaction between HIV-1 Nef and adaptor protein-2 reduces Nef-mediated CD4+ T cell apoptosis","year":2017,"lang":"en","type":"article","venue":"Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Apoptosis; Biology; Cell biology; Inhibitor of apoptosis domain; Signal transducing adaptor protein; Mutant; Human immunodeficiency virus (HIV); Small interfering RNA; Cell; Virology; Signal transduction; Programmed cell death; Cell culture; Transfection; Caspase; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002097801,0.0001450146,0.0002128884,0.00005525185,0.001125719,0.00006223037,0.0003137343,0.0002271009,0.0001403576],"category_scores_gemma":[0.0001751339,0.0000940789,0.00004712482,0.00002367346,0.0006004171,0.0001059669,0.0001858173,0.0003425399,0.001935181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002636326,"about_ca_system_score_gemma":0.00004154094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002183987,"about_ca_topic_score_gemma":0.00005070251,"domain_scores_codex":[0.9988291,0.000253611,0.0001744361,0.0002819975,0.00002988348,0.0004309605],"domain_scores_gemma":[0.9990431,0.0003036769,0.0001515519,0.0004197293,0.00003528519,0.00004666945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005741512,0.0001336744,0.01112414,0.00001043111,0.0003634133,0.00001150388,0.0002331328,1.742303e-7,0.9491477,0.0001419672,0.008054394,0.03020533],"study_design_scores_gemma":[0.003667855,0.001534199,0.1626093,0.00002051808,0.000100621,0.000040003,0.000339396,0.00000481624,0.5206541,0.0002978397,0.3104469,0.0002844363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907537,0.0008845667,0.00000960462,0.004895638,0.0002757633,0.0003701391,0.0001119104,0.00003528367,0.002663418],"genre_scores_gemma":[0.9954869,0.0002256319,0.00003000886,0.00003900657,0.00007922023,0.0001176963,0.0001690376,0.00001200608,0.003840454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4284936,"threshold_uncertainty_score":0.9988419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02015086779599536,"score_gpt":0.2711186596159046,"score_spread":0.2509677918199093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}