{"id":"W2621164287","doi":"10.1016/j.molcel.2017.05.029","title":"DNA Replication Is Required for Circadian Clock Function by Regulating Rhythmic Nucleosome Composition","year":2017,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Key Research and Development Program of China; U.S. Department of the Interior; Fonds de Recherche du Québec - Santé; National Institutes of Health; Cancer Prevention and Research Institute of Texas; Welch Foundation","keywords":"Biology; Circadian clock; DNA replication; Eukaryotic DNA replication; Control of chromosome duplication; Origin recognition complex; Circadian rhythm; Genetics; Cell biology; Pre-replication complex; Nucleosome; Licensing factor; DNA re-replication; Oscillating gene; Histone; Bacterial circadian rhythms; DNA; Gene; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017031,0.0001682477,0.0001580322,0.00006718189,0.0007946889,0.0002168815,0.0002460843,0.0001408239,0.00003462227],"category_scores_gemma":[0.0001320915,0.0001995069,0.000132254,0.00007628639,0.0000892782,0.0002974901,0.00005036624,0.0001115936,0.0001356672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007330068,"about_ca_system_score_gemma":0.00002867087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001423381,"about_ca_topic_score_gemma":6.628753e-7,"domain_scores_codex":[0.9984043,0.0000547234,0.0002529669,0.0007376313,0.0002094373,0.0003409898],"domain_scores_gemma":[0.9981509,0.00003829295,0.0003241504,0.001303753,0.00004733598,0.0001355726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003815387,0.00003202131,0.0000619635,0.00002955796,0.000002867056,0.000007172127,0.000108416,0.000009972908,0.9882715,0.00503088,0.001972185,0.004435272],"study_design_scores_gemma":[0.0007752867,0.00008531539,0.001025206,0.00002583654,0.00002516991,0.00001754779,0.000008560664,0.002458093,0.9568518,0.0009839397,0.03751823,0.0002250316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9724385,0.0001944784,0.01553142,0.00159028,0.0003878977,0.0008053452,0.00006447702,0.0001155811,0.008872006],"genre_scores_gemma":[0.9961196,0.000013973,0.0003535278,0.001555643,0.0001251196,0.00008332159,0.00005055364,0.00005128426,0.001647042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03554605,"threshold_uncertainty_score":0.8135655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02157431230832398,"score_gpt":0.2564140812789906,"score_spread":0.2348397689706666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}