{"id":"W2621221629","doi":"10.1017/cjn.2017.124","title":"P.039 mTOR inhibitors as a new therapeutic strategy in treatment resistant epilepsy in hemimegalencephaly: a case report","year":2017,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; Vancouver Biotech (Canada)","funders":"","keywords":"Hemimegalencephaly; Hemispherectomy; Tuberous sclerosis; Cortical dysplasia; Megalencephaly; Epilepsy; Medicine; Epileptogenesis; Hippocampal sclerosis; Ketogenic diet; Refractory (planetary science); Epilepsy surgery; PI3K/AKT/mTOR pathway; Pediatrics; Discovery and development of mTOR inhibitors; Psychiatry; Pathology; Temporal lobe","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000238559,0.001478603,0.0009953319,0.001859831,0.00206364,0.001520149,0.0009019781,0.005290819,0.002329198],"category_scores_gemma":[0.001174162,0.0005172177,0.001135575,0.0009690038,0.001141343,0.001999468,0.001043599,0.00340827,0.0007787458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001131615,"about_ca_system_score_gemma":0.0009321323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001772435,"about_ca_topic_score_gemma":0.002775927,"domain_scores_codex":[0.9996206,0.00005618142,0.00004559718,0.00008053513,0.00008298057,0.0001141097],"domain_scores_gemma":[0.9994916,0.0001284406,0.0001324615,0.00003822054,0.00002921201,0.0001800664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.000009952914,0.0000145097,0.0005011085,0.00001587881,0.000003966622,0.9977374,0.00003108908,0.00003970586,0.0002169134,0.0001706018,0.0002198943,0.001038958],"study_design_scores_gemma":[0.000004528232,0.00001504269,0.0002983796,0.00000893743,0.000005273843,0.998516,0.00002610673,0.0001418911,0.0001554507,0.0001205787,0.000704448,0.000003461376],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8545291,0.04635641,0.01361637,0.02418159,0.001799698,0.0005585244,0.0005926059,0.0005949296,0.05777086],"genre_scores_gemma":[0.9668064,0.009773456,0.006936459,0.004148048,0.00230235,0.0000904448,0.0002089809,0.00007101538,0.009662891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005290819,"threshold_uncertainty_score":0.008210421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07035639171354792,"score_gpt":0.3465283113601196,"score_spread":0.2761719196465717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}