{"id":"W2621233569","doi":"10.1136/bmjopen-2017-016276","title":"Application of pharmacogenomics to investigate adverse drug reactions to the disease-modifying treatments for multiple sclerosis: a case–control study protocol for dimethyl fumarate-induced lymphopenia","year":2017,"lang":"en","type":"article","venue":"BMJ Open","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of Manitoba; McGill University; University of British Columbia","funders":"Chugai Pharmaceutical; Multiple Sclerosis Society of Canada; EMD Serono; Genome British Columbia; Canadian Institutes of Health Research; Fondation Pour l'Audition; National Multiple Sclerosis Society; Children's Hospital Foundation; Multiple Sclerosis Society; Research Manitoba; European Committee for Treatment and Research in Multiple Sclerosis; Pfizer; Sanofi; Pfizer Canada; BC Children's Hospital; Biogen; Sanofi Genzyme; Genome Canada; Teva Pharmaceutical Industries; U.S. Department of Veterans Affairs","keywords":"Medicine; Pharmacogenomics; Multiple sclerosis; Dimethyl fumarate; Drug; Disease; Protocol (science); Adverse effect; Neurology; Disease control; Alternative medicine; Pharmacology; Intensive care medicine; Bioinformatics; Psychiatry; Internal medicine; Pathology; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08288506,0.003578433,0.005195684,0.00298494,0.002717391,0.00177063,0.004739739,0.006805278,0.02207084],"category_scores_gemma":[0.07387371,0.002067724,0.002669817,0.003411034,0.002394886,0.0013219,0.002368773,0.003297548,0.005471174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001781967,"about_ca_system_score_gemma":0.008286578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001893307,"about_ca_topic_score_gemma":0.00239997,"domain_scores_codex":[0.946897,0.03467448,0.007111259,0.003940786,0.005581169,0.001795243],"domain_scores_gemma":[0.9563972,0.01241872,0.006203549,0.01117419,0.01180405,0.002002264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.3859438,0.03518463,0.05024837,0.04404597,0.005250193,0.007128682,0.007607779,0.01051633,0.04702425,0.04806971,0.1298627,0.2291177],"study_design_scores_gemma":[0.1524915,0.09740977,0.170604,0.01465317,0.004203358,0.003205052,0.001290743,0.02815665,0.01779475,0.02503671,0.4841234,0.00103102],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.006637437,0.0002613718,0.01806969,0.0002637061,0.0003398923,0.9708537,0.002089859,0.00009718354,0.0013872],"genre_scores_gemma":[0.005284713,0.0001295,0.01398051,0.0001675074,0.00006206932,0.9791033,0.0006158001,0.00001343448,0.0006430399],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.08288506,"threshold_uncertainty_score":0.4383433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3393566296596583,"score_gpt":0.510696849976649,"score_spread":0.1713402203169906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}