{"id":"W2621324164","doi":"10.1016/j.abb.2017.05.017","title":"The type II isopentenyl Diphosphate:Dimethylallyl diphosphate isomerase (IDI-2): A model for acid/base chemistry in flavoenzyme catalysis","year":2017,"lang":"en","type":"review","venue":"Archives of Biochemistry and Biophysics","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institutes of Health; National Institute of General Medical Sciences; McGill University; Welch Foundation","keywords":"Chemistry; Flavin group; Isomerase; Cofactor; Isoprene; Isopentenyl pyrophosphate; Catalysis; Enzyme catalysis; Stereochemistry; Pyrophosphate; Biochemistry; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003448557,0.0009141783,0.001456742,0.00004063769,0.0006362995,0.000104065,0.001448055,0.0006619081,0.000003926993],"category_scores_gemma":[0.0004190748,0.0006929116,0.0008852041,0.0001674272,0.0009015705,0.00001453857,0.0008974263,0.0004097143,0.000001540126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002339465,"about_ca_system_score_gemma":0.0005595866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001665713,"about_ca_topic_score_gemma":0.000006393331,"domain_scores_codex":[0.9967813,0.00005358671,0.001008975,0.00122308,0.0002247726,0.0007083253],"domain_scores_gemma":[0.9968001,0.0002076399,0.001074787,0.00158907,0.00008862364,0.0002397257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005216675,0.0003304652,0.000005491678,0.00982505,0.0006775479,0.00001152696,0.00004191147,0.000006279349,0.6395634,0.00001046352,0.0003783618,0.3486278],"study_design_scores_gemma":[0.0005581154,0.0001265267,8.280841e-7,0.002667248,0.0006610724,0.00002956904,0.0000301681,0.0006249991,0.8459054,0.0001375115,0.1483757,0.0008828074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01045495,0.9863812,0.00008035851,0.00007156293,0.00008699156,0.0006470734,0.001867802,0.00001639591,0.000393669],"genre_scores_gemma":[0.02041824,0.9711826,0.0006202755,0.00002684646,0.0002713044,0.0001819594,0.002928311,0.00007859426,0.004291847],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.347745,"threshold_uncertainty_score":0.9995522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03192632949108096,"score_gpt":0.2950097164455545,"score_spread":0.2630833869544735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}