{"id":"W2621355506","doi":"10.1210/en.2017-00393","title":"Peptide Therapeutics for Weight Loss: Preventing Plasma Pancreatic Polypeptide Proteolysis","year":2017,"lang":"en","type":"letter","venue":"Endocrinology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"","keywords":"Proteolysis; Endocrinology; Internal medicine; Peptide; Pancreatic polypeptide; Chemistry; Medicine; Biology; Biochemistry; Insulin; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00158757,0.0009331955,0.001557951,0.0006107893,0.002641384,0.002772845,0.0008808249,0.03417827,0.004615509],"category_scores_gemma":[0.01475709,0.0004710882,0.001070928,0.0004429355,0.002400568,0.002917181,0.001652343,0.03689637,0.00394988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003264981,"about_ca_system_score_gemma":0.002232557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001261902,"about_ca_topic_score_gemma":0.002567415,"domain_scores_codex":[0.9985505,0.000385901,0.0002361206,0.0001490304,0.0004586432,0.0002197732],"domain_scores_gemma":[0.9959403,0.002337012,0.000402649,0.000104308,0.0005626963,0.0006531109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001729628,0.0001413126,0.001241077,0.0001653318,0.00003849677,0.01085639,0.0001183506,0.0001582756,0.0005170638,0.0067598,0.9356579,0.044173],"study_design_scores_gemma":[0.0008481253,0.0004043364,0.001923645,0.0009273177,0.00009707836,0.02124519,0.0004167521,0.001226326,0.0007667766,0.0327295,0.9393218,0.00009317983],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.0006619647,0.004878248,0.0001296476,0.9733636,0.018133,0.00001166969,0.00001790176,0.00001939318,0.002784621],"genre_scores_gemma":[0.009552659,0.006617319,0.0004917693,0.8504915,0.1258358,0.00005316866,0.00002931429,0.00002559934,0.006902991],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.03417827,"threshold_uncertainty_score":0.02368921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0291440171159862,"score_gpt":0.2875450373563008,"score_spread":0.2584010202403146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}