{"id":"W2621433260","doi":"10.1002/hon.2438_14","title":"PRELIMINARY EVIDENCE OF A MOLECULAR PREDICTOR OF TAZEMETOSTAT RESPONSE, BEYOND <scp>EZH</scp>2 MUTATION, IN <scp>NHL</scp> PATIENTS VIA CHARACTERIZATION OF ARCHIVE TUMOR AND CIRCULATING TUMOR <scp>DNA</scp>","year":2017,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Simon Fraser University; McGill University Health Centre","funders":"","keywords":"Medicine; EZH2; Internal medicine; Cancer research; Oncology; Clinical endpoint; Mutation; Gene; Clinical trial; Genetics; Histone; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009057839,0.0003150147,0.0008143567,0.0002030538,0.0001224479,0.00002153751,0.0004094722,0.0003696945,0.00000306406],"category_scores_gemma":[0.01547427,0.0002989384,0.0001449556,0.000166594,0.0005958712,0.00003668256,0.0004193215,0.0002092626,0.000001710846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003473807,"about_ca_system_score_gemma":0.0002095886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002092631,"about_ca_topic_score_gemma":0.00001367535,"domain_scores_codex":[0.9966697,0.0007296933,0.001165564,0.0006621823,0.000344796,0.0004280334],"domain_scores_gemma":[0.9952963,0.001677727,0.001813219,0.0005843008,0.0004673103,0.0001611491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001468228,0.0004058131,0.1476834,0.0002990084,0.00005045693,0.00005918648,0.0006916785,0.00006234904,0.8498964,0.0001291189,0.00002461492,0.0005511355],"study_design_scores_gemma":[0.00102816,0.003158067,0.4417954,0.0001591183,0.00005241976,0.00003481747,0.0001871112,0.0005047647,0.5516937,0.001116482,0.0002270349,0.00004291909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939663,0.00112415,0.003512206,0.0000406373,0.0001261075,0.0007997276,0.0001082236,0.00001179143,0.0003109023],"genre_scores_gemma":[0.9968535,0.0002126782,0.002455344,0.00007663317,0.00003642494,0.0000827328,0.0002193394,0.0000322747,0.00003112672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2982027,"threshold_uncertainty_score":0.9999463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01595120566443868,"score_gpt":0.28139603628771,"score_spread":0.2654448306232713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}