{"id":"W2621433260","doi":"10.1002/hon.2438_14","title":"PRELIMINARY EVIDENCE OF A MOLECULAR PREDICTOR OF TAZEMETOSTAT RESPONSE, BEYOND <scp>EZH</scp>2 MUTATION, IN <scp>NHL</scp> PATIENTS VIA CHARACTERIZATION OF ARCHIVE TUMOR AND CIRCULATING TUMOR <scp>DNA</scp>","year":2017,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Simon Fraser University; McGill University Health Centre","funders":"","keywords":"Medicine; EZH2; Internal medicine; Cancer research; Oncology; Clinical endpoint; Mutation; Gene; Clinical trial; Genetics; Histone; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005439765,0.0003012274,0.000336056,0.0005800204,0.0001502952,0.0005105168,0.0002400997,0.0003301235,0.002437564],"category_scores_gemma":[0.001432936,0.0001077948,0.0002106485,0.0004311009,0.0002027492,0.0002852083,0.0001634586,0.0005877309,0.0003166983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002036944,"about_ca_system_score_gemma":0.000235489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005804977,"about_ca_topic_score_gemma":0.001097876,"domain_scores_codex":[0.99976,0.00005472748,0.00002877266,0.00006443925,0.00006125728,0.00003086402],"domain_scores_gemma":[0.998786,0.0005670819,0.0003269055,0.00007435439,0.000112707,0.0001328127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004250372,0.0002303026,0.9234752,0.00007575218,0.000137735,0.0003588715,0.00005208699,0.0007863871,0.04884592,0.00006350965,0.0004006537,0.02132325],"study_design_scores_gemma":[0.0002618797,0.002857574,0.964389,0.00001222234,0.0001881,0.002573509,0.00006743918,0.003544265,0.02424676,0.0001177899,0.001731456,0.000009936566],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972366,0.000427573,0.0007750876,0.0001120789,0.00000712339,0.00003680827,0.0007164821,0.0000412143,0.0006469899],"genre_scores_gemma":[0.9976091,0.0001114372,0.0008480299,0.00004522224,0.00001799696,0.00001972763,0.001071517,0.000006050812,0.0002709236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002437564,"threshold_uncertainty_score":0.008154452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01595120566443868,"score_gpt":0.28139603628771,"score_spread":0.2654448306232713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}