{"id":"W2621569204","doi":"10.1200/jco.2017.35.15_suppl.1039","title":"Palbociclib (PAL) + letrozole (L) as first-line (1L) therapy (tx) in estrogen receptor-positive (ER+)/human epidermal growth factor receptor 2-negative (HER2−) advanced breast cancer (ABC): Efficacy and safety across patient (pt) subgroups.","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Palbociclib; Internal medicine; Hazard ratio; Letrozole; Breast cancer; Population; Progression-free survival; Oncology; Metastatic breast cancer; Adverse effect; Cancer; Estrogen receptor; Gynecology; Tamoxifen; Confidence interval; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003497652,0.0003107216,0.0006980338,0.0002514892,0.0001687057,0.0003466604,0.0003101146,0.0002835085,0.005398685],"category_scores_gemma":[0.0003543936,0.0001634008,0.0004393784,0.0002609593,0.0002030849,0.0002969415,0.0002095106,0.0008100044,0.000683125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006169634,"about_ca_system_score_gemma":0.0005456097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000570395,"about_ca_topic_score_gemma":0.003096324,"domain_scores_codex":[0.999886,0.00003850157,0.000007919738,0.00002395044,0.00002010961,0.0000235345],"domain_scores_gemma":[0.9998889,0.00002090221,0.00003669667,0.000006725248,0.000005577239,0.0000411859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5107751,0.0120575,0.02467754,0.001572318,0.001622304,0.0002245438,0.0002297624,0.002344001,0.02701545,0.000470002,0.00930915,0.4097022],"study_design_scores_gemma":[0.4659497,0.3877642,0.1072373,0.0002609963,0.002892761,0.001273848,0.0002234995,0.004028376,0.0114346,0.0008288733,0.01804567,0.00006022728],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912046,0.003095547,0.0002743561,0.0003432298,0.00004250321,0.0005791133,0.001364174,0.00007521903,0.003021237],"genre_scores_gemma":[0.99538,0.00125328,0.0002513267,0.0002763365,0.00003678837,0.0004239142,0.0009796864,0.000007330709,0.001391449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005398685,"threshold_uncertainty_score":0.01806045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05956333864583405,"score_gpt":0.4414005526879048,"score_spread":0.3818372140420708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}